AbDev: Antibody Developability Assessment Skill

What problem does it solve?

AbDev provides a fast, open-source workflow to assess antibody developability directly from amino acid sequences, surfacing liabilities, TAP metrics, and benchmarking against clinical therapeutics to guide lead optimization.

Core Features & Use Cases

• Layered evaluation across sequence liabilities, TAP profiling, and Thera-SAbDab benchmarking to generate a traffic-light developability scorecard.
• Supports VH/VL pairs and nanobody inputs, offline benchmarking, and JSON/scorecard outputs for integration into pipelines.
• Use case: screen multiple variants to triage candidates based on developed risk profiles and nearest-neighbor context.

Quick Start

Run AbDev on a VH:VL antibody sequence to generate a developability scorecard and machine-readable results.