alphafold-database

Retrieve AlphaFold predictions and confidence metrics by UniProt ID.

6|Updated Dec 30, 2025
One-click install
npx skills add https://github.com/pur3v4d3r/pur3-pkb-codebase --skill alphafold-database-pur3v4d3r
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: alphafold-database
Source: https://github.com/pur3v4d3r/pur3-pkb-codebase/tree/main/.claude/skills/__scientific-skills/alphafold-database
Command: npx skills add https://github.com/pur3v4d3r/pur3-pkb-codebase --skill alphafold-database-pur3v4d3r

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill includes references (resource) components.

What problem does it solve?

Access AlphaFold's protein structure predictions programmatically by UniProt ID, download coordinate files in mmCIF/PDB formats, and examine confidence metrics to guide biological insights.

Core Features & Use Cases

  • Retrieve AlphaFold predictions by UniProt accession and organism
  • Download model coordinates (mmCIF/bcif/pdb) and confidence data (pLDDT, PAE)
  • Analyze confidence metrics and integrate into computational workflows
  • Leverage bulk data access via Google Cloud for large-scale analyses

Quick Start

Query AlphaFold DB for a UniProt ID and download the corresponding structure file for immediate analysis.

Frequently Asked Questions about alphafold-database

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I download AlphaFold protein structures by UniProt ID?

Retrieve AlphaFold predictions by querying with a UniProt accession to get direct download links for coordinate files in mmCIF, bcif, or PDB formats. The system handles versioning and file-format variations with robust error handling for reliable access.

How can I access pLDDT and PAE confidence metrics for AlphaFold models?

Access pLDDT and PAE confidence metrics by retrieving AlphaFold predictions associated with a specific UniProt ID. The output clearly exposes these confidence data values alongside metadata and download URLs to support structure-based analyses.

Can I retrieve bulk AlphaFold datasets for large-scale protein analyses?

Retrieve bulk AlphaFold datasets for large-scale protein analyses by leveraging Google Cloud access. This approach supports extensive structure-based analyses in drug discovery and protein engineering workflows by exposing pLDDT and PAE data programmatically.

What is the best way to integrate AlphaFold predictions into drug discovery workflows?

Integrate AlphaFold predictions into drug discovery workflows by programmatically retrieving model coordinates and confidence metrics via UniProt ID. The system outputs clear URLs, metadata, and pLDDT or PAE metrics to support structure-based computational pipelines.

What happens if a UniProt ID query fails when fetching AlphaFold structures?

If a UniProt ID query fails when fetching AlphaFold structures, the system applies robust error handling for versioning and file-format variations. It ensures clear output of URLs, metadata, and metrics to prevent silent failures during retrieval.

Do I need a specific file format to analyze AlphaFold protein structures?

You do not need a single specific file format to analyze AlphaFold protein structures, as coordinate files are available in mmCIF, bcif, and PDB formats. The system handles these file-format variations to support diverse protein science workflows.