alphafold2

Predict protein structures for monomers and multimers with AlphaFold2.

288|34|Updated Jul 6, 2026
One-click install
npx skills add https://github.com/PKU-YuanGroup/OpenAI4S --skill alphafold2-pku-yuangroup
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: alphafold2
Source: https://github.com/PKU-YuanGroup/OpenAI4S/tree/main/skills/alphafold2
Command: npx skills add https://github.com/PKU-YuanGroup/OpenAI4S --skill alphafold2-pku-yuangroup

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill includes scripts (resource) components.

What problem does it solve?

This Skill solves the problem of predicting protein structures, which is crucial for fields like biomolecular research and drug discovery.

Core Features & Use Cases

  • Protein Structure Prediction: Predicts the 3D structure of proteins using the AlphaFold2 model.
  • Sequence Validation: Validates designed sequences using pLDDT, ipTM, and RMSD metrics.
  • MSA Prediction: Runs a quick multiple sequence alignment (MSA) prediction using the public MMseqs2 server.
  • Use Case: A researcher wants to analyze the structure of a protein they have designed. They can use this Skill to predict the protein's structure and validate the design.

Quick Start

Run the alphafold2 skill to predict the structure of a protein sequence provided in the 'sequence.fasta' file.

Frequently Asked Questions about alphafold2

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I predict protein structures using AlphaFold2 for biomolecular research?

You can predict protein structures by running the AlphaFold2 model on a provided 'sequence.fasta' file, which generates 3D structures for monomers and multimers.

Do I need a GPU to run AlphaFold2 protein structure prediction?

Yes, AlphaFold2 protein structure prediction requires a GPU and access to the ColabFold MSA server to perform multiple sequence alignment.

Can I validate designed protein sequences using AlphaFold2?

Yes, AlphaFold2 validates designed protein sequences by evaluating pLDDT, ipTM, and RMSD metrics to confirm structural confidence and stability.

Does AlphaFold2 support multiple sequence alignment for protein structure prediction?

Yes, AlphaFold2 supports multiple sequence alignment by running quick MSA predictions through the public MMseqs2 server to inform the protein structure prediction.

Can I predict multimer protein structures with AlphaFold2?

Yes, AlphaFold2 supports predicting both monomer and multimer protein structures, making it suitable for complex biomolecular research and drug discovery applications.