arboreto

Infers gene regulatory networks from gene expression data using scalable algorithms like GRBoost2 and GENIE3.

1|Updated Mar 12, 2026
One-click install
npx skills add https://github.com/yf8578/clawomics --skill arboreto-yf8578
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: arboreto
Source: https://github.com/yf8578/clawomics/tree/main/skills/arboreto
Command: npx skills add https://github.com/yf8578/clawomics --skill arboreto-yf8578

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill requires arboreto, and includes scripts (resource) and references (resource) components.

What problem does it solve?

This Skill automates the complex process of inferring gene regulatory networks (GRNs) from gene expression data, uncovering critical transcription factor-target gene relationships.

Core Features & Use Cases

  • GRN Inference: Utilizes scalable algorithms like GRNBoost2 and GENIE3 to identify regulatory interactions.
  • Data Compatibility: Works with various expression data formats (RNA-seq, single-cell).
  • Distributed Computing: Supports scaling analysis from single machines to clusters for large datasets.
  • Use Case: Analyze transcriptomics data to discover key regulators controlling gene expression in a specific biological condition, aiding in understanding disease mechanisms or cellular processes.

Quick Start

Use the arboreto skill to infer a gene regulatory network from the file 'expression_data.tsv' and save the output to 'network.tsv'.

Frequently Asked Questions about arboreto

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I infer gene regulatory networks from RNA-seq expression data?

To infer gene regulatory networks from RNA-seq data, apply scalable algorithms like GRNBoost2 or GENIE3 to your expression matrix to identify transcription factor-target gene relationships.

What is a gene regulatory network inference algorithm used for in transcriptomics?

A gene regulatory network inference algorithm identifies transcription factor-target relationships from transcriptomics expression data to uncover regulators controlling gene expression in specific biological conditions.

Can I use distributed computing for large-scale single-cell transcriptomics network inference?

Yes, distributed computing supports large-scale single-cell transcriptomics network inference by utilizing dask and parallel processing to scale gene regulatory network analysis from single machines to clusters.

Do I need pandas and dask to perform gene regulatory network inference?

Yes, you need pandas and dask for data manipulation and distributed parallel processing to execute scalable gene regulatory network inference algorithms like GRNBoost2.

What is the best way to scale GRNBoost2 for large gene expression datasets?

The best way to scale GRNBoost2 for large gene expression datasets is using distributed computation frameworks like dask to parallelize the transcription factor-target gene inference across clusters.

Why does gene regulatory network inference fail on extremely large expression matrices?

Gene regulatory network inference may fail on extremely large expression matrices if distributed computing environments like dask are not properly configured to handle memory and parallel processing overhead.