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bindcraft

Orchestrate end-to-end binder design workflows with AF2 validation and QC metrics.

25|5|Updated Mar 22, 2026
Search Tags:#workflow orchestration#protein design#binder design#af2 validation#design protocols#binding design
One-click install
npx skills add https://github.com/zongtingwei/Bioclaw_Skills_Hub --skill bindcraft-zongtingwei
Or copy as Structured Prompt for Agent▼
Please help me install this Agent Skill.
Skill: bindcraft
Source: https://github.com/zongtingwei/Bioclaw_Skills_Hub/tree/main/skills/protein-design/skills/bindcraft
Command: npx skills add https://github.com/zongtingwei/Bioclaw_Skills_Hub --skill bindcraft-zongtingwei

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill includes references (resource) components.

What problem does it solve?

Automates end-to-end binder design workflows to produce validated binder candidates and streamline protein engineering campaigns, reducing time from concept to actionable designs.

Core Features & Use Cases

  • End-to-end binder design orchestration with built-in AF2 validation
  • Support for multiple design protocols (fast, default, slow) and backbone/sequence optimization
  • Output includes designed binder backbones/sequences, QC metrics, and campaign-level metadata for downstream ranking (ipsae, protein-design-qc)

Quick Start

Provide a target structure and initial design constraints to start a BindCraft campaign and generate initial binder designs.

Frequently Asked Questions about bindcraft

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I automate end-to-end binder design workflows with AF2 validation?▼

BindCraft orchestrates end-to-end binder design workflows that include backbone and sequence optimization along with built-in AF2 validation, producing validated binder candidates and QC metrics for downstream ranking.

What design protocols are available for protein binder design campaigns?▼

Protein binder design campaigns support multiple design protocols including fast, default, and slow options, allowing you to balance speed and thoroughness during backbone and sequence optimization.

How do I start a BindCraft campaign to generate initial binder designs?▼

To start a binder design campaign, provide a target structure and initial design constraints, which triggers the workflow to generate designed binder backbones, sequences, and campaign-level metadata.

Does BindCraft work with Modal biomodals for protein design?▼

Yes, binder design workflows integrate with Modal biomodals to orchestrate protein design campaigns and output binding designs, QC metrics, and design campaign metadata.

What outputs do I get from a binder design workflow for downstream ranking?▼

Binder design workflows output designed binder backbones, sequences, QC metrics, and campaign-level metadata structured for downstream ranking using tools like ipsae or protein-design-qc.

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