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bio-clinical-databases-somatic-signatures

Official

Decode somatic mutational signatures in cancer.

Data & Analytics#cosmic#cancer-genomics#somatic#mutational-signatures#sigprofiler#mutationalpatterns#signature-fitting
Authorstellaromics
Version1.0.0
Installs0

System Documentation

What problem does it solve?

Extract and analyze mutational signatures from somatic variants to characterize mutagenic processes in cancer genomes.

Core Features & Use Cases

  • Extract de novo mutational signatures using SigProfilerExtractor to reveal underlying mutational processes in tumor samples.
  • Fit mutation data to known COSMIC signatures with MutationalPatterns to compare against established etiologies.
  • Use cases include identifying DNA damage mechanisms in cancer genomes and informing potential therapeutic decisions based on signature profiles.

Quick Start

Run SigProfiler on my VCF directory to extract mutational signatures and interpret the results.

Dependency Matrix

Required Modules

None required

Components

Standard package

💻 Claude Code Installation

Recommended: Let Claude install automatically. Simply copy and paste the text below to Claude Code.

Please help me install this Skill:
Name: bio-clinical-databases-somatic-signatures
Download link: https://github.com/stellaromics/fast-bioinfo/archive/main.zip#bio-clinical-databases-somatic-signatures

Please download this .zip file, extract it, and install it in the .claude/skills/ directory.
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