bio-single-cell

Perform deep learning-based single-cell RNA sequencing analysis with scvi-tools.

114|13|Updated Jan 17, 2026
One-click install
npx skills add https://github.com/frumu-ai/tandem --skill bio-single-cell
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: bio-single-cell
Source: https://github.com/frumu-ai/tandem/tree/main/src-tauri/resources/skill-templates/bio-single-cell
Command: npx skills add https://github.com/frumu-ai/tandem --skill bio-single-cell

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill requires python, bash, and includes scripts (resource) and references (resource) components.

What problem does it solve?

This Skill streamlines complex single-cell RNA sequencing data analysis by leveraging powerful deep learning models for tasks like batch correction, integration, and quality control.

Core Features & Use Cases

  • Data Integration & Batch Correction: Corrects for technical variations between datasets using scVI/scANVI.
  • Multi-modal Analysis: Analyzes CITE-seq and Multiome data with totalVI and MultiVI.
  • Quality Control: Performs essential QC analysis to ensure data reliability.
  • Use Case: Analyze a newly generated scRNA-seq dataset to identify cell types, correct for batch effects from different experimental runs, and visualize the integrated data.

Quick Start

Run standard QC analysis on your single-cell data using the provided script.

Frequently Asked Questions about bio-single-cell

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I perform batch correction on scRNA-seq data using deep learning?

Batch correction on scRNA-seq data uses deep learning models like scVI and scANVI to correct technical variations between experimental runs. This Skill applies these scvi-tools models to integrate datasets and remove batch effects.

Can I analyze CITE-seq and spatial transcriptomics data with scvi-tools?

Yes, scvi-tools supports analyzing CITE-seq and spatial transcriptomics data. This Skill handles multi-modal analysis with totalVI and MultiVI, and performs spatial transcriptomics deconvolution.

What is the best way to integrate multiple single-cell RNA sequencing datasets?

The best way to integrate multiple scRNA-seq datasets is using deep learning-based data integration. This Skill leverages the scvi-tools ecosystem to align datasets and perform comprehensive quality control.

Do I need a specific Python environment to run scRNA-seq quality control?

Yes, you need a Python and bash environment with specific bioinformatics packages installed. This Skill requires these dependencies to execute deep learning-based single-cell RNA sequencing analysis and QC.

Does single-cell analysis with scvi-tools support RNA velocity and label transfer?

Yes, single-cell analysis with scvi-tools supports RNA velocity and label transfer. This Skill also handles ATAC-seq analysis and multiome data integration using the scverse deep learning ecosystem.