bio-structure-annotation

Protein structure prediction and structure-based annotation accelerate omics workflows by using predicted 3D models to identify similar folds and assign functions, replacing traditional sequence-based similarity searches.

ColabFold and Boltz support multi-chain protein complex structure prediction, allowing you to model interactions within proteomics and structural biology workflows before searching structures with Foldseek.

Foldseek annotates structural hits by searching predicted protein structures against structural databases to identify similar folds, enabling function annotation tasks across single proteins and complexes.

The structure prediction and annotation workflow supports tm-vec embedding, applying it alongside Boltz or ColabFold prediction and Foldseek searching to satisfy requirements for structure-based annotation.

The best way to integrate structure prediction and annotation into proteomics workflows is using an integrated pipeline that applies tm-vec embedding, Boltz or ColabFold prediction, and Foldseek searching to accelerate analysis.