bio-workflows-multi-omics-pipeline

Integrate multi-omics datasets with MOFA2, mixOmics, and SNF to discover shared biological signals.

Updated Mar 30, 2026
One-click install
npx skills add https://github.com/ya-way/cytoclaw-skills --skill bio-workflows-multi-omics-pipeline
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: bio-workflows-multi-omics-pipeline
Source: https://github.com/ya-way/cytoclaw-skills/tree/main/workspace/skills/bio-wf-multi-omics-pipeline
Command: npx skills add https://github.com/ya-way/cytoclaw-skills --skill bio-workflows-multi-omics-pipeline

SYSTEM DOCUMENTATION & REQUIREMENTS

What problem does it solve?

Integrates multiple omics datasets (transcriptomics, proteomics, metabolomics) to uncover shared biology, enabling cross-modal biomarker discovery and patient stratification.

Core Features & Use Cases

  • End-to-end multi-omics integration using MOFA2, DIABLO, and SNF for both unsupervised discovery and supervised analyses.
  • Data harmonization, feature selection, factor interpretation, and downstream analyses across modalities.
  • Use Case: Discover shared biological signals and stratify patients using integrated omics signatures.

Quick Start

Load transcriptomics, proteomics, and metabolomics data and run the end-to-end multi-omics pipeline to discover shared signals across modalities.

Frequently Asked Questions about bio-workflows-multi-omics-pipeline

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I integrate multi-omics data for patient stratification and biomarker discovery?

Integrate multi-omics data for patient stratification by loading transcriptomics, proteomics, and metabolomics datasets into an end-to-end pipeline that discovers shared biological signals across modalities.

What is the best way to run unsupervised and supervised multi-omics integration together?

Run unsupervised and supervised multi-omics integration together using a workflow that applies MOFA2, DIABLO, and SNF to handle data harmonization, feature selection, and cross-modality factor interpretation.

Can I use MOFA2 and mixOmics for cross-modal pathway interpretation?

Yes, you can use MOFA2 and mixOmics for cross-modal pathway interpretation by applying their factor interpretation and feature selection capabilities to uncover shared biology across multiple omics layers.

How does SNF work for integrating transcriptomics and proteomics datasets?

SNF integrates transcriptomics and proteomics datasets by fusing similarity networks across modalities, enabling the discovery of shared biological signals and accurate patient stratification.

Do I need to perform data harmonization before running multi-omics integration workflows?

Data harmonization is handled within the multi-omics integration workflow itself, ensuring cross-modality datasets are properly aligned before feature selection and downstream analyses are executed.