bioinformatics

Access genomics and computational biology workflows for sequencing and variant calling.

Updated Jun 25, 2026
One-click install
npx skills add https://github.com/Rheasilvia/hermes-desktop --skill bioinformatics-rheasilvia
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: bioinformatics
Source: https://github.com/Rheasilvia/hermes-desktop/tree/main/optional-skills/research/bioinformatics
Command: npx skills add https://github.com/Rheasilvia/hermes-desktop --skill bioinformatics-rheasilvia

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill requires biopython, pysam, cyvcf2, pybedtools, pyBigWig, scikit-allel, anndata, scanpy, mygene.

What problem does it solve?

This skill solves the fragmentation of bioinformatics tools by providing a centralized gateway to hundreds of specialized genomics, sequencing, and computational biology workflows.

Core Features & Use Cases

  • Comprehensive Indexing: Access a curated library of 385 reference skills and 33 executable pipeline bundles.
  • Domain Coverage: Supports diverse tasks including variant calling, RNA-seq analysis, single-cell processing, and structural biology.
  • Use Case: If you need to perform a differential expression analysis on bulk RNA-seq data, this skill directs you to the appropriate pipeline and provides the necessary parameter guides and environment setup instructions.

Quick Start

Use the bioinformatics skill to fetch the variant calling reference guide and explain the standard GATK workflow parameters.

Frequently Asked Questions about bioinformatics

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I find a standard workflow for RNA-seq differential expression analysis?

RNA-seq differential expression analysis workflows are available through a curated library of 385 reference skills and 33 executable pipeline bundles. This gateway provides parameter guides and environment setup instructions to direct you to the appropriate pipeline for bulk RNA-seq data processing.

Can I use this to access workflows for single-cell sequencing and variant calling?

Single-cell sequencing and variant calling workflows are supported through the unified interface. It retrieves reference patterns and executable pipelines for diverse computational biology tasks, including structural biology and expression analysis.

What's the best way to get GATK workflow parameters for variant calling?

GATK workflow parameters for variant calling are retrieved using the bioinformatics gateway to fetch the reference guide. It explains standard parameters and directs you to the appropriate pipeline bundle for complex biological data processing.

Does this gateway support reproducible research with external repositories?

Reproducible research is supported through integration with external repositories for standardized bioinformatics analysis. This centralizes fragmented genomics tools into a comprehensive index of computational biology workflows.

Do I need Biopython and pysam installed to run sequencing pipelines?

Biopython, pysam, and other dependencies like cyvcf2 and scanpy are required to execute the sequencing pipelines. The gateway provides the necessary environment setup instructions alongside the retrieved reference patterns.

Why use a centralized gateway for computational biology workflows instead of standalone tools?

A centralized gateway solves the fragmentation of bioinformatics tools by providing access to hundreds of specialized genomics workflows. It ensures standardized analysis and reproducible research by integrating external repositories with executable pipeline bundles.