by-research

Automate cross-database target research for antibody campaigns with an 8-phase pipeline.

104|10|Updated Mar 23, 2026
One-click install
npx skills add https://github.com/001TMF/blatant-why --skill by-research
Or copy as Structured Prompt for Agentβ–Ό
Please help me install this Agent Skill.
Skill: by-research
Source: https://github.com/001TMF/blatant-why/tree/main/templates/.claude/skills/by-research
Command: npx skills add https://github.com/001TMF/blatant-why --skill by-research

SYSTEM DOCUMENTATION & REQUIREMENTS

πŸ’‘ This Skill includes scripts (resource) and references (resource) components.

What problem does it solve?

BY Research automates comprehensive, cross-database target research for antibody/binder campaigns, consolidating data from PDB, UniProt, SAbDab and PubMed into an actionable evidence package to reduce manual research overhead.

Core Features & Use Cases

  • 8-phase pipeline (SCOPE β†’ PLAN β†’ RETRIEVE β†’ TRIANGULATE β†’ SYNTHESIZE β†’ CRITIQUE β†’ REFINE β†’ PACKAGE) with persistent memory and quality gates.
  • Multi-source data integration from PDB, UniProt, SAbDab, PubMed, bioRxiv to build target profiles, evidence maps, and design inputs.
  • Outputs designed to feed downstream orchestration and campaign planning tools (scope.json, sources.json, validated_findings.json, critique.json, research.md, and design_recommendation.json).
  • Resume and auditability through checkpoints and a race-safe progression log for mid-session recovery.

Quick Start

Initiate a new design campaign by running the BY Research workflow to generate a target research plan.

Frequently Asked Questions about by-research

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I automate target research for an antibody design campaign?β–Ό

Automating target research for an antibody design campaign involves using a structured 8-phase pipeline that retrieves and triangulates data from PDB, UniProt, SAbDab, and PubMed into an actionable evidence package, reducing manual literature review overhead.

Can I resume an interrupted cross-database literature review mid-session?β–Ό

Yes, you can resume an interrupted cross-database literature review mid-session using persistent memory, quality gates, and a race-safe progression log that allows recovery and progression from the exact checkpoint where you left off.

What is the best way to consolidate structural and literature data for epitope analysis?β–Ό

The best way to consolidate structural and literature data for epitope analysis is through a multi-source integration workflow that synthesizes evidence from PDB, UniProt, SAbDab, and PubMed into validated findings and structured design recommendations.

Does this antibody research pipeline output structured files for downstream orchestration?β–Ό

Yes, this antibody research pipeline outputs structured JSON files including scope.json, sources.json, validated_findings.json, and design_recommendation.json, explicitly designed to feed directly into downstream orchestration and campaign planning tools.

What are the limitations of manual prior art review for binder campaigns?β–Ό

Manual prior art review for binder campaigns often suffers from fragmented data across PDB, UniProt, SAbDab, and PubMed, creating integration overhead that a structured, automated triangulation pipeline with explicit quality gates is designed to eliminate.

Do I need to manually check PDB and UniProt before starting target investigations?β–Ό

No, you do not need to manually check PDB and UniProt before starting target investigations, as the pipeline automatically retrieves and triangulates multi-source data during its initial phases to build comprehensive target profiles.