candidate-ranker

Score drug and phytochemical candidates for Oral Mucositis using weighted multi-criteria analysis.

4|1|Updated Jan 8, 2024
One-click install
npx skills add https://github.com/OpenSourcePharmaFoundation/ospf-ayurveda-kg --skill candidate-ranker
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: candidate-ranker
Source: https://github.com/OpenSourcePharmaFoundation/ospf-ayurveda-kg/tree/main/.claude/skills/candidate-ranker
Command: npx skills add https://github.com/OpenSourcePharmaFoundation/ospf-ayurveda-kg --skill candidate-ranker

SYSTEM DOCUMENTATION & REQUIREMENTS

What problem does it solve?

It reduces decision fatigue in Oral Mucositis (OM) drug discovery by producing a clear, reproducible ranked shortlist from multi-source biomedical evidence.

Core Features & Use Cases

  • Multi-criteria prioritization (MCDA): Scores each candidate 0–10 across OM-relevant dimensions (target relevance, mechanism strength, drug-likeness, ADMET, clinical precedent, traditional use evidence, pathway coverage, feasibility) with defined weights.
  • OM-specific mapping and gap analysis: Assigns candidates to OM Sonis model phases (1–5), then identifies which phases and dimensions are underserved.
  • Conservative handling of incomplete data: Uses confidence levels and flags missing evidence without inflating scores.

Quick Start

Rank a set of OM drug and phytochemical candidates from processed CSV evidence and produce candidate scorecards plus a ranking summary table and phase coverage gap analysis.

Frequently Asked Questions about candidate-ranker

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I rank drug repurposing candidates for oral mucositis using multi-criteria scoring?

You rank oral mucositis drug repurposing candidates by computing a weighted multi-criteria score across target relevance, mechanism strength, ADMET, and clinical precedent. The process outputs transparent scorecards, a ranking table, and phase coverage gap analysis.

What is multi-criteria decision analysis for drug repurposing?

Multi-criteria decision analysis for drug repurposing scores each candidate 0–10 across biomedical dimensions like target relevance, ADMET, and traditional use evidence. It applies defined weights to heterogeneous data to produce a reproducible ranked shortlist.

Can I prioritize phytochemical candidates for oral mucositis with incomplete ADMET data?

You can prioritize phytochemical candidates with incomplete ADMET data through conservative scoring. The mechanism flags missing evidence with confidence levels without inflating scores, ensuring disqualifying safety criteria still exclude candidates.

How do I identify oral mucositis phase coverage gaps in a drug candidate shortlist?

You identify oral mucositis phase coverage gaps by assigning ranked candidates to Sonis model phases 1–5. The analysis outputs which phases and scoring dimensions are underserved, helping direct future drug discovery efforts.

What inputs do I need for multi-criteria drug candidate ranking?

Multi-criteria drug candidate ranking requires assembling identifiers and descriptors from target profiling, mechanism evidence, physicochemical assessments, and traditional-use signals. You provide processed CSV evidence to generate scorecards and a ranking summary.

Are there limitations to using multi-criteria scoring for natural product prioritization?

A limitation of multi-criteria scoring for natural product prioritization is its dependence on heterogeneous biomedical evidence availability. Missing evidence is conservatively flagged rather than estimated, which can lower scores for poorly studied phytochemicals despite potential efficacy.