circdna

Run the nf-core/circdna pipeline to identify circular DNA from sequencing data.

1|Updated Jun 19, 2026
One-click install
npx skills add https://github.com/danilomonge/nf-claw --skill circdna
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: circdna
Source: https://github.com/danilomonge/nf-claw/tree/main/pipelines/circdna
Command: npx skills add https://github.com/danilomonge/nf-claw --skill circdna

SYSTEM DOCUMENTATION & REQUIREMENTS

What problem does it solve?

This Skill removes the guesswork from running the nf-core/circdna workflow so you can identify circular DNA in sequencing datasets with the right inputs, options, and release-specific behavior from the start.

Core Features & Use Cases

  • Circular DNA detection: Supports analysis paths for extrachromosomal circular DNA discovery across WGS, ATAC-seq, and Circle-Seq style data.
  • Reproducible pipeline execution: Works with pinned Nextflow releases, validated parameters, and documented outputs so runs are easy to repeat and audit.
  • Practical research workflows: Helps bioinformatics users choose the correct input format, circular DNA identifier, and optional preprocessing or reference settings for their dataset.
  • Example use case: A researcher can submit a samplesheet for paired-end sequencing reads, select the appropriate detection branch, and produce standardized result folders plus provenance records for downstream interpretation.

Quick Start

Use the circdna skill to run nf-core/circdna on your samplesheet with the required input format, outdir, and circle identifier for your dataset.

Frequently Asked Questions about circdna

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I identify circular DNA from WGS and ATAC-seq data?

You identify circular DNA from WGS and ATAC-seq data by running the nf-core/circdna pipeline on a samplesheet with paired-end reads to produce standardized result folders and provenance records.

What is the best way to run the nf-core/circdna pipeline reproducibly?

The best way to run the nf-core/circdna pipeline reproducibly is to use pinned Nextflow releases, schema-validated parameters, and documented outputs to ensure runs are easy to repeat and audit.

Can I use Circle-Seq data for extrachromosomal circular DNA detection?

Yes, you can use Circle-Seq data for extrachromosomal circular DNA detection by selecting the appropriate detection branch within the supported analysis paths of the workflow.

What input format is required to discover circular DNA using Nextflow?

The input format required to discover circular DNA using Nextflow is a samplesheet containing paired-end sequencing reads, along with an output directory and a circle identifier.

Do I need schema-validated parameters to run a circular DNA detection pipeline?

Yes, you need schema-validated parameters to run the circular DNA detection pipeline because they enforce correct inputs and release-specific behavior for reliable research analysis.