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clinvar

Build candidate landscapes and inventories from exact ClinVar variant matches.

475|61|Updated May 28, 2026
Search Tags:#genomics#variant analysis#ClinVar#evidence analysis#genetic research
One-click install
npx skills add https://github.com/exon-research/genomi --skill clinvar
Or copy as Structured Prompt for Agent▼
Please help me install this Agent Skill.
Skill: clinvar
Source: https://github.com/exon-research/genomi/tree/main/skills/clinvar
Command: npx skills add https://github.com/exon-research/genomi --skill clinvar

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill requires clinvar-grch38, clinvar-grch37, and includes scripts (resource) and references (resource) components.

What problem does it solve?

This Skill provides the ability to build and inspect ClinVar evidence for variant analysis, helping users understand clinical labels, carrier context, and drug-response rows.

Core Features & Use Cases

  • ClinVar Evidence Analysis: Build candidate landscapes from exact ClinVar matches.
  • Variant Matching: Materialize exact ClinVar matches for comparable Active Genome Index variants.
  • Candidate Inventory: Build a deterministic candidate inventory and candidate review groups from exact ClinVar matches.
  • Use Case: When a user needs to understand the clinical significance of a variant, this Skill can be used to analyze ClinVar evidence and provide insights into the variant's potential impact.

Quick Start

Use the clinvar skill to match variants in the Active Genome Index against ClinVar data.

Frequently Asked Questions about clinvar

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I match genetic variants against ClinVar data for clinical significance?▼

To match genetic variants against ClinVar data, this Skill materializes exact ClinVar matches for comparable Active Genome Index variants to help you understand clinical labels, carrier context, and drug-response rows.

What is ClinVar evidence analysis used for in variant analysis?▼

ClinVar evidence analysis is used to build candidate landscapes and deterministic inventories from exact matches, providing insights into a genetic variant's potential clinical impact and significance.

How do I build a candidate inventory from exact ClinVar matches?▼

You can build a deterministic candidate inventory and candidate review groups from exact ClinVar matches by analyzing the evidence built from your Active Genome Index variant data.

Do I need an Active Genome Index to analyze ClinVar evidence?▼

Yes, you need an Active Genome Index and the ClinVar library (GRCh37 or GRCh38) to analyze ClinVar evidence, match variants, and build candidate landscapes.

Can I use ClinVar GRCh37 and GRCh38 data for genetic research?▼

Yes, this Skill supports ClinVar GRCh37 and ClinVar GRCh38 dependencies to analyze clinical evidence, carrier context, and drug-response rows for genetic variant research.

What are the limitations of building candidate landscapes from ClinVar matches?▼

Candidate landscapes are built exclusively from exact ClinVar matches, meaning variants without exact corresponding entries in the ClinVar library will not be included in the deterministic inventory or review groups.

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