crispr-screen-qc
CommunityQC for pooled CRISPR screens in one run.
Data & Analytics#visualization#quality-control#qc#crispr#replicate-correlation#count-matrix#gini-index
AuthorMDhewei
Version1.0.0
Installs0
System Documentation
What problem does it solve?
Quality control of pooled CRISPR screens by validating library representation, sequencing depth, and replicate consistency using sgRNA read counts.
Core Features & Use Cases
- Computes library representation, read-depth metrics, and Gini index to detect under-represented guides.
- Calculates replicate correlations and generates a comprehensive QC report with plots for quick assessment.
- Supports control vs targeting guide analysis to monitor library bias and quality before downstream analyses.
Quick Start
Run the QC workflow on a count matrix with optional sample metadata to produce QC summary and visualizations.
Dependency Matrix
Required Modules
pandasnumpymatplotlibscipy
Components
scripts
💻 Claude Code Installation
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Please help me install this Skill: Name: crispr-screen-qc Download link: https://github.com/MDhewei/bioinfor-claw/archive/main.zip#crispr-screen-qc Please download this .zip file, extract it, and install it in the .claude/skills/ directory.
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