Query DepMap Chronos scores and gene effects across cancer cell lines.
npx skills add https://github.com/SciMate-AI/scicli --skill depmap-scimate-ai
Please help me install this Agent Skill. Skill: depmap Source: https://github.com/SciMate-AI/scicli/tree/main/internal/skills/bundled/claude-scientific-skills/skills/depmap Command: npx skills add https://github.com/SciMate-AI/scicli --skill depmap-scimate-ai
Query and analyze cancer dependency data to identify gene essentialities and drug sensitivities across cancer cell lines.
Query a target gene's Chronos score across cell lines to identify cancer-selective dependencies.
High-intent search queries and answers about installing and using this skill.
To identify gene essentiality, query Chronos scores and gene effects across cancer cell lines to pinpoint cancer-selective dependencies. This allows you to filter cell lines and compute selectivity for specific targets.
Find synthetic-lethal partners by analyzing co-essentiality and comparing pan-cancer versus cancer-selective dependencies across cell lines. This highlights selective vulnerabilities linked to specific genetic features.
Yes, you can perform biomarker-driven analyses linking mutations, expression, and copy number to dependencies. This workflow computes associations between genetic features and drug sensitivities across cell lines.
Yes, analyzing Chronos scores and gene dependency requires access to the DepMap portal or downloadable datasets. The Skill provides filtering and biomarker association utilities to process this data.
The best way to validate cancer targets is querying Chronos scores to identify selective dependencies and potential synthetic-lethal partners. This provides reproducible analysis workflows for target validation.
mkurmanAnalyze DepMap CRISPR Chronos scores and gene-effect data for cancer cell line dependencies.
K-Dense-AIIdentify cancer-specific gene dependencies from DepMap CRISPR Chronos scores.
dralkhIdentify cancer-specific gene dependencies and synthetic lethal partners from DepMap datasets.
qinyan-aiQuery DepMap data for gene dependencies and drug sensitivities in cancer cell lines.
