drop

Run the DROP nf-core pipeline to detect aberrant expression, splicing, and mono-allelic expression from RNA sequencing data.

1|Updated Jun 19, 2026
One-click install
npx skills add https://github.com/danilomonge/nf-claw --skill drop
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: drop
Source: https://github.com/danilomonge/nf-claw/tree/main/pipelines/drop
Command: npx skills add https://github.com/danilomonge/nf-claw --skill drop

SYSTEM DOCUMENTATION & REQUIREMENTS

What problem does it solve?

This Skill helps you run the DROP nf-core pipeline without manual schema hunting, so you can analyze RNA sequencing data for aberrant expression, aberrant splicing, and mono-allelic expression with the correct parameters and outputs.

Core Features & Use Cases

  • End-to-End RNA Outlier Detection: Executes a production-ready workflow for RNA outlier discovery across expression, splicing, and allele-specific signals.
  • Samplesheet-Driven Runs: Supports different input modes such as BAM or CRAM based samples, gene counts with annotations, or splice count directories.
  • Validated Pipeline Configuration: Surfaces required inputs, optional analysis groups, genome settings, and release-specific flags so runs stay reproducible and schema-compliant.

Quick Start

Ask the assistant to run the DROP pipeline on your samplesheet with the right genome, output directory, and sequencing input type for your dataset.

Frequently Asked Questions about drop

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I detect aberrant expression and splicing in RNA sequencing data?

You can detect aberrant expression and splicing by running an nf-core pipeline that processes RNA sequencing inputs like BAM or CRAM files and gene counts to identify expression and splicing outliers across genome-specific workflows.

What is monoallelic expression detection and how does it work with RNA-seq data?

Monoallelic expression detection identifies allele-specific expression outliers from RNA sequencing data. It works by running an nf-core pipeline that processes BAM or CRAM inputs and gene counts to pinpoint aberrant allele-specific signals.

Can I use BAM or CRAM files to detect RNA outliers with Nextflow?

Yes, you can use BAM or CRAM files to detect RNA outliers with Nextflow. The pipeline supports samplesheet-driven runs that accept raw BAM or CRAM inputs, gene counts with annotations, or splice count directories.

What inputs do I need to run an RNA-seq outlier detection pipeline?

To run an RNA-seq outlier detection pipeline, you need validated input files such as raw BAM or CRAM, gene counts, and splice counts. You also must specify the output directory and genome parameters for your workflow.

How do I configure the DROP nf-core pipeline for reproducible RNA analysis?

You configure reproducible RNA analysis by applying validated required inputs, optional analysis groups, genome settings, and release-specific flags. This ensures your runs remain schema-compliant and reproducible across different sequencing input modes.