drop

What problem does it solve?

This Skill helps you run the DROP nf-core pipeline without manual schema hunting, so you can analyze RNA sequencing data for aberrant expression, aberrant splicing, and mono-allelic expression with the correct parameters and outputs.

Core Features & Use Cases

• End-to-End RNA Outlier Detection: Executes a production-ready workflow for RNA outlier discovery across expression, splicing, and allele-specific signals.
• Samplesheet-Driven Runs: Supports different input modes such as BAM or CRAM based samples, gene counts with annotations, or splice count directories.
• Validated Pipeline Configuration: Surfaces required inputs, optional analysis groups, genome settings, and release-specific flags so runs stay reproducible and schema-compliant.

Quick Start

Ask the assistant to run the DROP pipeline on your samplesheet with the right genome, output directory, and sequencing input type for your dataset.