drug-drug-interaction-analysis

Analyze drug-drug interactions for up to five medications via KEGG DDI.

1.1k|132|Updated Apr 13, 2023
One-click install
npx skills add https://github.com/PharMolix/OpenBioMed --skill drug-drug-interaction-analysis
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: drug-drug-interaction-analysis
Source: https://github.com/PharMolix/OpenBioMed/tree/main/skills/drug-drug-interaction-analysis
Command: npx skills add https://github.com/PharMolix/OpenBioMed --skill drug-drug-interaction-analysis

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill includes references (resource) components.

What problem does it solve?

Analyze potential drug-drug interactions (DDIs) for multiple medications using KEGG's DDI database and provide structured insights.

Core Features & Use Cases

  • Resolve drug names to KEGG IDs and fetch interaction data
  • Return severity, mechanism, and drug context to support clinical decisions
  • Use cases include polypharmacy safety reviews, pre-prescription checks, and pharmacology research

Quick Start

Provide a list of up to five drug names to analyze potential interactions using KEGG DDI.

Frequently Asked Questions about drug-drug-interaction-analysis

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I check drug-drug interactions for multiple medications using KEGG?

To check drug-drug interactions using KEGG, provide a list of up to five medication names. The tool resolves these names to KEGG IDs, queries the DDI database, and returns structured interaction details including severity, mechanism, and CYP involvement.

What information is included in a polypharmacy safety review for drug interactions?

A polypharmacy safety review for drug interactions includes severity levels, underlying mechanisms, and CYP enzyme involvement. It evaluates up to five concurrent medications to support clinical decisions by aggregating interaction context from the KEGG database.

Can I analyze more than five drugs in a single interaction check?

No, you cannot analyze more than five drugs in a single interaction check. The tool is specifically designed to process a maximum of five medications per query to ensure accurate DDI resolution and KEGG API retrieval.

How do CYP enzymes affect the drug interaction data returned?

CYP enzyme involvement is a core component of the drug interaction data returned. The analysis highlights specific CYP-mediated mechanisms to help identify metabolic competition or inhibition within your polypharmacy regimen.

Does the tool work with generic drug names or require specific KEGG IDs?

The tool works directly with standard drug names. It automatically resolves your provided medication names into the required KEGG IDs before querying the DDI API, so you do not need to supply specific identifiers manually.

What is the best way to use DDI analysis for pre-prescription clinical checks?

The best way to use DDI analysis for pre-prescription clinical checks is to input the proposed medication regimen of up to five drugs. The tool evaluates interaction severity and mechanisms to inform clinical decision-support workflows before prescribing.