skills.rest
Juancho032007
Juancho032007COMMUNITY
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ensembl-database

Query Ensembl genes, sequences, variants, and orthologs via REST API.

Updated Aug 23, 2026
Search Tags:#bioinformatics#genomics#gene annotation#Ensembl API#comparative genomics#sequence retrieval#variant analysis
One-click install
npx skills add https://github.com/Juancho032007/claude-scientific-skills --skill ensembl-database
Or copy as Structured Prompt for Agent▼
Please help me install this Agent Skill.
Skill: ensembl-database
Source: https://github.com/Juancho032007/claude-scientific-skills/tree/main/scientific-databases/ensembl-database
Command: npx skills add https://github.com/Juancho032007/claude-scientific-skills --skill ensembl-database

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill requires ensembl_rest, requests, and includes scripts (resource) and references (resource) components.

What problem does it solve?

Accessing and integrating diverse genomic data from the Ensembl database can be complex and time-consuming, hindering rapid genomic research. This Skill streamlines queries for genes, sequences, variants, and comparative genomics, accelerating your analysis and reducing manual data wrangling.

Core Features & Use Cases

  • Gene & Sequence Retrieval: Look up gene information by symbol or Ensembl ID, and fetch DNA, transcript, or protein sequences for over 250 species.
  • Variant Analysis: Query genetic variation data and predict functional consequences of variants using the Variant Effect Predictor (VEP).
  • Comparative Genomics: Easily find orthologs (same gene in different species) and paralogs (related genes in the same species) to understand evolutionary relationships.
  • Use Case: A geneticist needs to find all orthologs of a human gene (e.g., BRCA2) in mice, retrieve their protein sequences, and analyze any known variants. This skill automates the entire data retrieval and initial analysis, providing a comprehensive overview.

Quick Start

To look up a human gene by symbol: from ensembl_rest import EnsemblClient client = EnsemblClient() gene_data = client.symbol_lookup(species='human', symbol='BRCA2') print(gene_data)