ensembl-database

To retrieve gene sequences and orthologs across species, query the Ensembl REST endpoints to fetch gene data by symbol or Ensembl ID. You can obtain DNA, transcripts, and proteins, then map cross-species orthology for comparative genomics.

Yes, you can map genomic coordinates between GRCh37 and GRCh38 assembly versions. The Skill queries Ensembl REST endpoints to perform assembly mapping, allowing you to align and coordinate older datasets with current genome builds.

You can perform variant analysis and VEP predictions on vertebrate genomes by querying the Ensembl REST endpoints. The Skill fetches variant data and applies Variant Effect Predictor logic to retrieve detailed predictions for genomic variants.

Yes, the Ensembl data retrieval tool supports batch requests and rate limiting for production use. It implements robust error handling and batch endpoint support to ensure reliable querying of gene, sequence, and variant data across species.

The best way to look up gene information by symbol or Ensembl ID is to query the Ensembl REST endpoints. This retrieves comprehensive gene details, sequence data, and variant predictions for vertebrate genomes directly.

You need assembly mapping when working with older genomic datasets because genome builds like GRCh37 and GRCh38 use different coordinate systems. Mapping coordinates between assemblies ensures accurate region overlaps and gene data alignment with current references.