esm-biohub
CommunityRun Biohub ESM models for protein design at scale
Education & Research#embeddings#esm#multi-chain#protein-design#structure-prediction#biohub-platform#saes
AuthorLiorZ
Version1.0.0
Installs0
System Documentation
What problem does it solve?
This skill enables researchers to run Biohub's world-model protein suite (ESMC, ESMFold2, ESM3, and SAEs) locally via an Apptainer / Singularity image or through the Biohub Platform, unlocking embeddings, structure predictions, mutation scoring, and de novo design workflows without manual tool integration.
Core Features & Use Cases
- Local, containerized access to ESMC, ESMFold2, ESM3, and SAE pipelines for embedding, structure prediction, and design tasks.
- End-to-end workflows including per-residue embeddings, zero-shot mutation scoring, inverse folding, multi-chain folding, and binder/design validation, with optional MSAs and CCD-based modifications.
- Cloud integration via the Biohub Platform API for large-scale, batch processing and cloud-hosted model access when local resources are constrained.
Quick Start
Start by building or obtaining the Esm SIF image, launch the container, and follow the cookbook tutorials to run embeddings, folding, and SAE feature extraction.
Dependency Matrix
Required Modules
None requiredComponents
references
💻 Claude Code Installation
Recommended: Let Claude install automatically. Simply copy and paste the text below to Claude Code.
Please help me install this Skill: Name: esm-biohub Download link: https://github.com/LiorZ/protein-design-skills/archive/main.zip#esm-biohub Please download this .zip file, extract it, and install it in the .claude/skills/ directory.
Agent Skills Search Helper
Install a tiny helper to your Agent, search and equip skill from 510,000+ vetted skills library on demand.