fair-esm2

Generate protein sequence embeddings using Meta AI's ESM-2 model.

Updated Aug 23, 2026
One-click install
npx skills add https://github.com/guanxiaol/open-science --skill fair-esm2
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: fair-esm2
Source: https://github.com/guanxiaol/open-science/tree/main/runtime/skills/fair-esm2
Command: npx skills add https://github.com/guanxiaol/open-science --skill fair-esm2

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill requires fair-esm, and includes scripts (resource) components.

What problem does it solve?

This Skill simplifies the process of embedding proteins with ESM-2 for various applications like machine learning, mutation effect scoring, and contact prediction.

Core Features & Use Cases

  • Protein Embedding: Embed proteins for machine learning tasks.
  • Mutation Scoring: Score mutation effects on proteins.
  • Contact Prediction: Predict protein contacts from sequences.
  • Use Case: Use this Skill to embed a protein sequence and extract embeddings for further analysis.

Quick Start

Use the fair-esm2 skill to generate embeddings for the protein sequence 'MQIFVKTLTGKTITLEVEPSDTIENVK'.

Frequently Asked Questions about fair-esm2

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I generate protein embeddings for machine learning tasks?

Protein embeddings for machine learning are generated by processing amino acid sequences through Meta AI's ESM-2 model to extract numerical vector representations for downstream analysis.

Can I score mutation effects on proteins using ESM-2?

Yes, you can score mutation effects on proteins using ESM-2. The Skill applies the model to evaluate sequence changes and calculate the resulting mutation scores.

What is the best way to predict protein contacts from a sequence?

Predicting protein contacts from a sequence is handled by applying the ESM-2 model to extract structural relationship data. This Skill utilizes the model's output to identify contact predictions.

Do I need a GPU to run ESM-2 protein embedding?

Yes, you need a GPU with CUDA 11.7 or higher to run ESM-2 protein embedding. Additionally, the 'fair-esm' package must be installed to support the model's processing requirements.

Does the fair-esm2 Skill work without the fair-esm package?

No, the fair-esm2 Skill does not work without the 'fair-esm' package. This dependency is required to execute the underlying ESM-2 model operations for embedding generation and scoring.