find-cohort-gap

Convert cohort metadata into ranked research topic proposals with novelty evidence.

243|60|Updated Apr 6, 2026
One-click install
npx skills add https://github.com/Aperivue/medsci-skills --skill find-cohort-gap
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: find-cohort-gap
Source: https://github.com/Aperivue/medsci-skills/tree/main/skills/find-cohort-gap
Command: npx skills add https://github.com/Aperivue/medsci-skills --skill find-cohort-gap

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill includes references (resource) components.

What problem does it solve?

Systematically discovers novel, publishable research topics from a cohort database by translating cohort metadata into literature gaps and actionable research questions.

Core Features & Use Cases

  • Cohort Intake: capture metadata (N, follow-up, variable categories, endpoints, strengths)
  • PI Profiling: align topics with PI expertise using PubMed signals
  • Intersection Matrix: cross-cluster cohorts vs PI strengths to generate candidate topics
  • Literature Saturation Scan: assess novelty via PubMed searches and identify blue/green/yellow/red zones
  • 6-Pattern Scoring: evaluate each finalist against 6 universal patterns to rank viability
  • Feasibility Gate: verify sample size, endpoints, missing data, and IRB considerations
  • Output: ranked topic proposals with comparative tables and one-pager templates

Quick Start

Provide a cohort profile and optional PI details, then run the skill to generate ranked gap proposals and one-pager outputs.

Frequently Asked Questions about find-cohort-gap

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I find publishable research gaps from an existing cohort database?

To find publishable cohort gaps, convert your cohort metadata into literature gaps using saturation scanning and feasibility gating, generating ranked topic proposals with evidence of novelty.

What is literature saturation scanning and how does it identify novel research topics?

Literature saturation scanning assesses topic novelty via PubMed searches, categorizing candidate research areas into blue, green, yellow, and red zones to identify unsaturated literature gaps.

How do I align cohort data with a PI's expertise to generate feasible research questions?

Align cohort data with PI expertise by cross-referencing PubMed signals in an intersection matrix, matching PI strengths against cohort variables to generate high-priority, data-driven questions.

Can I use cohort metadata from national registries and EMRs for topic discovery?

Yes, you can use cohort metadata from healthcare systems, national registries, and institutional EMRs for topic discovery, provided the data includes sample size, endpoints, and variable categories.

What is the 6-pattern scoring method for ranking research topic viability?

The 6-pattern scoring method evaluates finalist research topics against six universal patterns to rank their viability, ensuring selected literature gaps have high publishable potential.

What cohort metadata is required to pass feasibility gating for research proposals?

Feasibility gating requires cohort metadata including sample size, follow-up duration, variable categories, endpoints, missing data assessment, and IRB considerations to verify research viability.