genenmf-metaprogram-discovery
CommunityCross-sample gene programs via per-sample NMF
Authortony-zhelonkin
Version1.0.0
Installs0
System Documentation
What problem does it solve?
Identify reproducible transcriptional programs across multiple single-cell samples by performing per-sample non-negative matrix factorization and deriving consensus meta-programs.
Core Features & Use Cases
- Per-sample NMF to learn gene programs in each donor/sample.
- Consensus meta-program discovery across donors, enabling cross-patient signatures without batch correction.
- Score cells by meta-program signatures using UCell within Seurat workflows; applicable to tumor heterogeneity and multi-donor studies.
Quick Start
Split your Seurat object by donor, run multiNMF across samples, then extract and score meta-programs.
Dependency Matrix
Required Modules
None requiredComponents
Standard package💻 Claude Code Installation
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Please help me install this Skill: Name: genenmf-metaprogram-discovery Download link: https://github.com/tony-zhelonkin/SciAgent-toolkit/archive/main.zip#genenmf-metaprogram-discovery Please download this .zip file, extract it, and install it in the .claude/skills/ directory.
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