genie3

Community

Fast, end-to-end SE(3)-equivariant protein design.

AuthorLiorZ
Version1.0.0
Installs0

System Documentation

What problem does it solve?

Genie3 automates end-to-end de novo protein design workflows from installation to design evaluation, enabling researchers to explore scaffolded designs and binders at scale.

Core Features & Use Cases

  • End-to-end diffusion-model design for monomers, motifs, and binders, with multi-GPU and multi-node scaling.
  • Flexible workflows: unconditional design, motif scaffolding, and target binder design, plus beam search and iterative conditioning.
  • Integrations with backends like ProteinMPNN and ColabFold, plus problem-prep and result-reduction tooling to produce publishable designs.

Quick Start

Clone the Genie 3 repo, install the environment, and run a tiny unconditional example with the included YAML.

Dependency Matrix

Required Modules

None required

Components

references

💻 Claude Code Installation

Recommended: Let Claude install automatically. Simply copy and paste the text below to Claude Code.

Please help me install this Skill:
Name: genie3
Download link: https://github.com/LiorZ/protein-design-skills/archive/main.zip#genie3

Please download this .zip file, extract it, and install it in the .claude/skills/ directory.
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