Compute identity-by-state similarity between 23andMe genotype files and reference genomes.
npx skills add https://github.com/ClawBio/ClawBio --skill genome-compare
Please help me install this Agent Skill. Skill: genome-compare Source: https://github.com/ClawBio/ClawBio/tree/main/skills/genome-compare Command: npx skills add https://github.com/ClawBio/ClawBio --skill genome-compare
Comparing personal genotype files to public references and estimating ancestry typically requires multiple bioinformatics tools, reference panels, and custom scripts; this skill collapses that workflow into a single reproducible pipeline that runs locally and preserves user privacy.
Compare my 23andMe file to George Church's reference and generate a reproducible report with IBS metrics, per-chromosome plots, and ancestry estimates.
High-intent search queries and answers about installing and using this skill.
Compute pairwise identity-by-state similarity between your 23andMe file and a reference genome to quantify genetic relatedness via SNP overlap counts and concordance metrics across all chromosomes.
Estimate continental ancestry proportions (AFR, EUR, EAS, SAS, AMR) from 23andMe genotype data by applying an EM admixture algorithm to an ancestry-informative markers frequency panel.
Identity-by-state (IBS) is a metric that quantifies genetic relatedness by comparing shared SNP alleles between two genomes, outputting concordance statistics and per-chromosome breakdowns.
Yes, the workflow requires parsed rsID genotype inputs in 23andMe format, a reference 23andMe file, and an AIMs frequency panel to output IBS metrics, per-chromosome stats, and ancestry proportions.
Run the genome comparison pipeline to produce a markdown report, structured JSON results, figures, and a reproducibility bundle containing commands and checksums for full auditability.
Comparing personal genotype files to public references like PGP-1 is limited to research and demo workflows, requiring overlapping rsID markers and relying on local execution to preserve user privacy.
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