hic-aggregation
CommunityMerge and analyze 3D chromatin contact maps from Hi-C data.
Content & Communication#bioinformatics#data aggregation#hic#chromatin#genome architecture#3d contacts
Authorammawla
Version1.0.0
Installs0
System Documentation
What problem does it solve?
This Skill enables users to compile comprehensive catalogs of chromatin loops by aggregating Hi-C loop calls across multiple experiments, donors, and labs, providing insights into 3D genome organization.
Core Features & Use Cases
- Union Catalog Construction: Merge BEDPE loop calls at resolution-aware anchors to produce a comprehensive set of chromatin contacts.
- Experiment Screening: Identify and select high-quality Hi-C datasets passing ENCODE standards for inclusion.
- Use Case: A researcher wants to combine loops from pancreas tissue across different labs to identify conserved structural features near the MYC gene.
Quick Start
Use this Skill to aggregate Hi-C loop calls from multiple experiments and generate a union catalog of chromatin contacts in your region of interest.
Dependency Matrix
Required Modules
None requiredComponents
scriptsreferences
💻 Claude Code Installation
Recommended: Let Claude install automatically. Simply copy and paste the text below to Claude Code.
Please help me install this Skill: Name: hic-aggregation Download link: https://github.com/ammawla/encode-toolkit/archive/main.zip#hic-aggregation Please download this .zip file, extract it, and install it in the .claude/skills/ directory.
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