One-click install
npx skills add https://github.com/silverstein/claude-scientific-skills-desktop --skill hypogenic-silverstein
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: hypogenic
Source: https://github.com/silverstein/claude-scientific-skills-desktop/tree/main/corpus/hypogenic
Command: npx skills add https://github.com/silverstein/claude-scientific-skills-desktop --skill hypogenic-silverstein

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill includes references (resource) components.

What problem does it solve?

Hypogenic helps you turn datasets and domain context into testable scientific hypotheses, then evaluate competing explanations against observational evidence to support research discovery.

Core Features & Use Cases

  • Automated hypothesis generation: Produce multiple candidate hypotheses from structured inputs and refine them iteratively based on performance.
  • Literature + data integration: Combine insights extracted from research papers with empirical patterns using HypoRefine and Union-style approaches.
  • Hypothesis inference and evaluation: Run inference over hypothesis banks using dataset-specific label extraction to quantify support, contradiction, or neutrality.

Use case: you have an observational dataset (and optional relevant papers) and you need a systematic set of hypotheses to explain the patterns, then test those hypotheses using a consistent evaluation pipeline for downstream research decisions.

Quick Start

Tell the AI to generate hypotheses from your dataset by running hypogenic_generation with method hypogenic, using your config.yaml, and requesting 20 hypotheses for the provided task.

Frequently Asked Questions about hypogenic

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I generate testable scientific hypotheses from an observational dataset?

You can generate testable scientific hypotheses from structured observational datasets by providing domain context, extracting dataset-specific labels, and applying configuration-driven LLM prompting to produce candidate explanations.

Can I integrate literature evidence with empirical data for hypothesis refinement?

Yes, you can integrate literature evidence with empirical data for hypothesis refinement by combining insights extracted from research papers with observational patterns using HypoRefine and Union-style approaches.

How does hypothesis inference and evaluation work over a hypothesis bank?

Hypothesis inference and evaluation over a hypothesis bank works by running inference using dataset-specific label extraction to quantify support, contradiction, or neutrality against observational evidence.

What is the best way to systematically test competing explanations against observational evidence?

The best way to systematically test competing explanations against observational evidence is to apply a consistent evaluation pipeline that uses dataset-aligned label extraction and iterative refinement for reliable inference.

Do I need a config.yaml file to generate hypotheses from my dataset?

Yes, you need a config.yaml file to generate hypotheses from your dataset, as the process requires configuration-driven LLM prompting to run the hypogenic_generation method and request a specified number of hypotheses.

When should I not use automated hypothesis generation for research discovery?

You should not use automated hypothesis generation for research discovery when you lack structured observational datasets or domain context, as reliable inference requires dataset-aligned label extraction and iterative refinement.