m4-research

Guide clinical researchers through structured interviews to generate formal research protocols.

40|17|Updated Oct 27, 2025
One-click install
npx skills add https://github.com/hannesill/m4 --skill m4-research
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: m4-research
Source: https://github.com/hannesill/m4/tree/main/src/m4/skills/system/m4-research
Command: npx skills add https://github.com/hannesill/m4 --skill m4-research

SYSTEM DOCUMENTATION & REQUIREMENTS

What problem does it solve?

This skill guides investigators through a structured clinical research session, interview-driven planning, and the creation of a formal protocol to ensure rigor and reproducibility.

Core Features & Use Cases

  • Interview-driven planning: Guides researchers to elicit precise research questions, study design, outcomes, populations, and confounders.
  • Structured protocol generation: Produces a formal Research Protocol including design, datasets, covariates, analysis plan, and safety guardrails.
  • Reproducibility & integrity: Emphasizes data/version documentation, bias checks, and transparent decision records.
  • Use Case: Ideal for planning cohort studies, hypothesis testing, or comparative analyses across clinical datasets.

Quick Start

Describe your study goal and dataset to generate an end-to-end clinical research protocol.

Frequently Asked Questions about m4-research

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I design a clinical research protocol for MIMIC-IV cohort studies?

Design a clinical research protocol for MIMIC-IV through a guided interview process that elicits precise research questions, study populations, and confounders. The session outputs a formal protocol document covering datasets, covariates, analysis plans, and bias guardrails.

What is interview-driven protocol generation for clinical research?

Interview-driven protocol generation uses structured prompts to help clinical researchers define hypotheses, outcomes, and study design step-by-step. It ensures rigorous planning by applying reproducibility checks and bias guardrails before finalizing the formal research protocol.

Can I use this structured research workflow for comparative analyses across eICU datasets?

Yes, you can use this structured research workflow for comparative analyses across eICU datasets. The protocol template accommodates planning for multiple clinical datasets by documenting design choices, covariates, and transparent decision records to ensure reproducibility.

How do I add reproducibility guardrails to a clinical research session?

Add reproducibility guardrails by following the phased workflow that enforces data version documentation, bias checks, and transparent decision records. The protocol generation process integrates these integrity measures directly into the final research plan.

Does this research planning approach work for hypothesis testing and cohort exploration?

Yes, this research planning approach works for both hypothesis testing and cohort exploration. The guided interview elicits specific study goals and datasets, then structures the protocol to support rigorous comparative analyses across clinical data.

What are the limitations of interview-based clinical protocol design?

The interview-based clinical protocol design focuses on planning and documentation rather than executing statistical analyses. It provides the formal research protocol, guardrails, and analysis plan, but does not process the clinical datasets or run the comparative tests itself.