methylation-aggregation
CommunityIntegrate WGBS data to map tissue-wide DNA methylation profiles.
Authorammawla
Version1.0.0
Installs0
System Documentation
What problem does it solve?
This Skill enables the comprehensive integration and analysis of whole-genome bisulfite sequencing data across multiple experiments, facilitating accurate tissue-level methylation mapping.
Core Features & Use Cases
- Data Aggregation: Combine CpG methylation data from diverse WGBS experiments to generate a unified methylation landscape.
- Regional Analysis: Identify hypomethylated regions, unmethylated and partially methylated domains that highlight regulatory elements and heterochromatin.
- Use Case: Building a methylation atlas for pancreatic tissue by aggregating data from various labs and donors to study tissue-specific epigenetic regulation.
Quick Start
Use the methylation-aggregation skill to process multiple WGBS bedMethyl files for your tissue of interest and generate an integrated methylation profile.
Dependency Matrix
Required Modules
bedtoolspython3awk
Components
scriptsreferences
💻 Claude Code Installation
Recommended: Let Claude install automatically. Simply copy and paste the text below to Claude Code.
Please help me install this Skill: Name: methylation-aggregation Download link: https://github.com/ammawla/encode-toolkit/archive/main.zip#methylation-aggregation Please download this .zip file, extract it, and install it in the .claude/skills/ directory.
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