microbiome-curation

Decompose microbiome pathophysiology into modular graph nodes with evidence tagging.

50|9|Updated Dec 4, 2025
One-click install
npx skills add https://github.com/monarch-initiative/dismech --skill microbiome-curation
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: microbiome-curation
Source: https://github.com/monarch-initiative/dismech/tree/main/.claude/skills/microbiome-curation
Command: npx skills add https://github.com/monarch-initiative/dismech --skill microbiome-curation

SYSTEM DOCUMENTATION & REQUIREMENTS

What problem does it solve?

Curates and structures microbiome-related pathophysiology into modular, traceable graph nodes to improve knowledge base consistency and reuse.

Core Features & Use Cases

  • Atomic node decomposition of dysbiosis mechanisms (e.g., loss of diversity, keystone taxa, colonization resistance)
  • Graph-based downstream relationships and evidence tagging to support causal reasoning
  • Evidence integration with literature and BugSigDB signatures to anchor assertions

Quick Start

Create a modular microbiome mechanism graph for a given disorder, decomposing it into atomic nodes with downstream edges and linked evidence.

Frequently Asked Questions about microbiome-curation

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I structure microbiome dysbiosis mechanisms into a knowledge graph?

To structure microbiome dysbiosis mechanisms, decompose pathophysiology into atomic graph nodes with downstream edges. This creates modular, traceable relationships for conditions like IBD by linking ecological shifts to causal reasoning pathways.

What is the best way to curate microbiome disease mechanisms for a knowledge base?

Curating microbiome disease mechanisms requires breaking down dysbiosis processes into atomic nodes with evidence tagging and ontology term bindings. This ensures knowledge base consistency by anchoring assertions to literature and BugSigDB signatures.

Can I map keystone taxa and colonization resistance to specific disease pathways?

Yes, you can map keystone taxa and colonization resistance by creating atomic nodes that represent these ecological concepts. These nodes link via downstream edges to metabolite pathways, enabling structured causal reasoning across conditions like C. diff infections.

How do I add evidence tags and ontology terms to microbiome pathophysiology nodes?

Add evidence tags and ontology term bindings directly to atomic microbiome pathophysiology nodes during decomposition. This satisfies structured description requirements by anchoring mechanistic assertions to literature and BugSigDB signatures.

Does microbiome mechanism curation support integration with BugSigDB signatures?

Microbiome mechanism curation supports evidence integration with BugSigDB signatures. This anchors atomic graph nodes representing dysbiosis mechanisms to validated microbial signatures, improving traceability and causal reasoning within the knowledge base.

What conditions can I model using atomic node decomposition for microbiome pathophysiology?

You can model various conditions including IBD, C. diff infections, and obesity using atomic node decomposition. This approach breaks down disease-specific dysbiosis mechanisms into modular ecological and metabolite pathways for graph-based reasoning.