motif-analysis

What problem does it solve?

Researchers need to identify transcription factor binding motifs within genomic peak regions to understand regulatory interactions and validate experimental results.

Core Features & Use Cases

• Motif discovery and enrichment: Applies HOMER and MEME Suite to find de novo and known motifs within peak datasets.
• Co-binding analysis: Identifies potential co-regulators and enhancer factors by revealing enriched motifs in ChIP-seq and ATAC-seq peaks.
• Use Case: For example, analyzing CTCF peaks from liver tissue to find associated transcription factors such as HNF4A or FOXA2, thus elucidating tissue-specific regulatory networks.

Quick Start

Provide peak regions in BED format, and the tool will extract sequences, run motif enrichment analysis, and interpret results.