neuropixels-analysis

To run spike sorting on Neuropixels recordings with Kilosort4, you can use this Skill to load raw data, apply preprocessing and motion correction, and execute the sorting algorithm to extract single neuron activity.

Electrophysiology recordings can be loaded from SpikeGLX, OpenEphys, and NWB formats, allowing you to ingest raw neural data directly into the analysis pipeline for subsequent spike sorting.

Yes, after spike sorting you can perform automated or AI-assisted curation to classify and assess the quality of single neurons, streamlining the validation of your sorted units.

The best way to export curated neural data is by using the export functions to generate Phy and NWB formats, ensuring your spike sorting results are ready for publication and downstream research.

Yes, SpikeInterface supports motion correction for high-density probe data, allowing you to mitigate spatial drift artifacts in Neuropixels recordings before performing spike sorting.

While automated curation significantly speeds up unit validation, it is designed to assist rather than fully replace manual inspection, meaning you should still review quality metrics for critical publication-ready datasets.