What problem does it solve?
This Skill addresses the complexity of spatial transcriptomics by providing a standardized, reproducible framework for loading, quality-controlling, and analyzing spatial data across multiple platforms like Visium, Xenium, and MERFISH.
Core Features & Use Cases
- Multi-Platform Support: Unified loading and validation for Visium, Xenium, MERFISH, CosMx, and Stereo-seq.
- Spatial Statistics: Advanced analysis including neighborhood enrichment, co-occurrence, and spatially variable gene detection using squidpy.
- Cell-Type Mapping: Integration of scRNA-seq references for spot deconvolution and label transfer via cell2location and Tangram.
- Use Case: Analyze a Visium slide to identify spatially contiguous tissue domains and map cell-type composition to understand the tumor microenvironment.
Quick Start
Use the omics-spatial skill to load your spatial data and perform initial quality control by running the omics_runtime read_spatial command followed by the spatial_qc method.