onek-genomes

Ingest 1000 Genomes VCFs and sample metadata into Hail MatrixTables.

Updated Feb 2, 2024
One-click install
npx skills add https://github.com/bigbio/hvantk --skill onek-genomes
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: onek-genomes
Source: https://github.com/bigbio/hvantk/tree/main/hvantk/skills/onek_genomes
Command: npx skills add https://github.com/bigbio/hvantk --skill onek-genomes

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill requires hail, requests, and includes scripts (resource) components.

What problem does it solve?

This Skill solves the complexity of managing and integrating large-scale 1000 Genomes Project high-coverage variant data and sample metadata into Hail-based multiomics analysis pipelines.

Core Features & Use Cases

  • Variant Matrix Construction: Imports per-chromosome bgzipped VCFs into a unified Hail MatrixTable for scalable analysis.
  • Sample Metadata Integration: Automatically fetches and processes IGSR canonical sample panels to annotate variant cohorts.
  • Use Case: Researchers can use this to build a standardized 1000 Genomes reference cohort, enabling rapid population-level variant frequency analysis or ancestry inference.

Quick Start

Run the hvantk reprocess onek-genomes:variants command with your local VCF directory path to build the variant cohort MatrixTable.

Frequently Asked Questions about onek-genomes

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I ingest 1000 Genomes VCFs into Hail MatrixTables for variant analysis?

To ingest 1000 Genomes VCFs into Hail MatrixTables, run the provided reprocess command with your local VCF directory path to build a unified variant cohort for scalable analysis.

What is the best way to integrate IGSR sample metadata into a Hail genomics workflow?

The best way to integrate IGSR sample metadata into a Hail genomics workflow is using this Skill, which automatically fetches and processes canonical sample panels to annotate variant cohorts.

Do I need Hail installed to process 1000 Genomes high-coverage variant callsets?

Yes, you need Hail installed to process 1000 Genomes high-coverage variant callsets, as this Skill depends on the Hail framework to construct MatrixTables for large-scale genomic data pipelines.

Can I build a standardized reference cohort for ancestry inference using 1000 Genomes data?

Yes, you can build a standardized 1000 Genomes reference cohort for ancestry inference by using this Skill to ingest variant callsets and integrate sample metadata into Hail MatrixTables.

Does this Skill support large-scale population-level variant annotation tasks?

Yes, this Skill supports large-scale population-level variant annotation tasks by facilitating the integration of 1000 Genomes Project variant data and sample metadata into Hail workflows.