What problem does it solve?
pacsomatic removes the manual friction of preparing and launching matched tumor-normal somatic analysis runs, giving operators a validated path from BAM inputs to reproducible Nextflow execution.
Core Features & Use Cases
- Input validation: Checks tumor and normal BAM paths, sample identifiers, reference mode, and available runtime prerequisites before launch.
- Artifact generation: Builds a pacsomatic-compatible samplesheet, generated params YAML, and a reusable launch script.
- Multi-backend execution: Supports local execution and scheduler submission for LSF, Slurm, PBS, and SGE with report-friendly run artifacts.
- Troubleshooting support: Helps triage missing inputs, dependency gaps, and submission failures with clear next-step guidance.
Quick Start
Ask the pacsomatic skill to validate your matched tumor-normal BAM inputs, generate the samplesheet and launch script, and prepare a dry-run or scheduler submission with the reference mode you want.