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personal-genomics-analysis

Convert 23andMe raw genotype files into annotated markdown genomics reports.

Updated May 6, 2026
Search Tags:#pharmacogenomics#clinvar#23andme#health insights#personal genomics#ancestry estimation#sqlite analysis
One-click install
npx skills add https://github.com/Uniquecrete/ThinkFasterv1 --skill personal-genomics-analysis-uniquecrete
Or copy as Structured Prompt for Agent▼
Please help me install this Agent Skill.
Skill: personal-genomics-analysis
Source: https://github.com/Uniquecrete/ThinkFasterv1/tree/main/Skills/personal-genomics-analysis
Command: npx skills add https://github.com/Uniquecrete/ThinkFasterv1 --skill personal-genomics-analysis-uniquecrete

SYSTEM DOCUMENTATION & REQUIREMENTS

What problem does it solve?

It transforms raw 23andMe genome files into an actionable, structured analysis that surfaces health risks, ancestry, traits, and drug sensitivity without you manually searching across datasets.

Core Features & Use Cases

  • Clinical variant screening: Cross-references your SNPs against ClinVar to highlight known pathogenic and likely pathogenic variants with evidence context.
  • Pharmacogenomics mapping: Detects relevant drug–gene interactions using PharmGKB-style pharmacogenomic markers to produce a medication sensitivity summary.
  • Trait, ancestry, and reporting outputs: Builds local SQLite databases, runs trait/ancestry marker checks, generates visualizations (e.g., ancestry charts), and compiles a personalized markdown report.

Quick Start

Provide your 23andMe raw tab-delimited genotype file to run the full pipeline and generate the personalized genomics report.

Frequently Asked Questions about personal-genomics-analysis

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I analyze my 23andMe raw data for health risks and drug sensitivity?▼

To analyze 23andMe raw data, provide the tab-delimited genotype file to generate a personalized markdown report cross-referencing ClinVar and PharmGKB databases. The pipeline builds local SQLite databases to annotate pathogenic variants and medication interactions.

What is pharmacogenomics mapping for personal genomics data?▼

Pharmacogenomics mapping detects drug-gene interactions using PharmGKB-style markers to produce a medication sensitivity summary. It cross-references your SNPs against clinical resources to identify how your genotype may influence drug response.

Can I use my 23andMe file to estimate ancestry and look up trait markers?▼

Yes, you can use a 23andMe file to estimate ancestry and look up trait markers. The pipeline runs ancestry marker checks and generates visualizations like ancestry charts alongside the health-risk and pharmacogenomic report.

Do I need any special database setup to run personal genomics analysis?▼

No external database setup is required for personal genomics analysis. The pipeline automatically builds local SQLite databases including genome.db, clinvar.db, and pharmgkb.db from your ingested rsid and genotype data.

What format does 23andMe raw data need to be in for clinical variant screening?▼

For clinical variant screening, 23andMe raw data must be in a tab-delimited text file containing rsid, chromosome, position, and genotype columns. The pipeline ingests this structure to cross-reference SNPs against ClinVar.

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