Personal Genomics

Analyze consumer DNA data locally and export JSON reports.

Updated Apr 9, 2026
One-click install
npx skills add https://github.com/jakechen1/echo-research-framework --skill personal-genomics-jakechen1
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: Personal Genomics
Source: https://github.com/jakechen1/echo-research-framework/tree/main/skills/personal-genomics
Command: npx skills add https://github.com/jakechen1/echo-research-framework --skill personal-genomics-jakechen1

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill includes references (resource) components.

What problem does it solve?

Enables private, offline DNA analysis for AI agents by transforming raw consumer DNA data into actionable insights without sending data to cloud services.

Core Features & Use Cases

  • Pharmacogenomics analysis and drug-gene interactions to guide medication decisions.
  • Haplogroup, ancestry, and polygenic risk score analyses from 23andMe, AncestryDNA, MyHeritage, or VCF inputs.
  • Agent-friendly exports (JSON) and human-readable reports for decision support.

Quick Start

Run the analysis on a local DNA file (e.g., ~/dna-analysis/raw_data.txt) to generate reports in ~/dna-analysis/reports.

Frequently Asked Questions about Personal Genomics

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I analyze consumer DNA data offline for AI agents?

To analyze consumer DNA data offline for AI agents, run the analysis on a local DNA file to generate agent-friendly JSON exports and human-readable reports. This process supports 23andMe, AncestryDNA, MyHeritage, and VCF input formats.

What pharmacogenomics and ancestry insights can I extract from 23andMe or VCF files?

From 23andMe or VCF files, you can extract pharmacogenomics drug-gene interactions, haplogroups, ancestry, and polygenic risk scores. This offline analysis evaluates over 1600 markers to generate actionable health and ancestry reports.

Does local DNA analysis support VCF and MyHeritage input formats?

Yes, local DNA analysis supports VCF, 23andMe, AncestryDNA, and MyHeritage input formats. The offline processing pipeline accepts these raw consumer DNA files to produce structured JSON and human-readable reports.

How do I generate JSON reports from raw DNA data for decision support?

You generate JSON reports from raw DNA data by running the local analysis pipeline on your input file. The tool transforms raw genomic data into agent-friendly JSON exports and human-readable reports for pharmacogenomics and ancestry decision support.

Can I run polygenic risk score analysis without sending my DNA data to cloud services?

Yes, you can run polygenic risk score analysis entirely offline without sending DNA data to cloud services. The local processing safeguards privacy by analyzing 1600+ markers and generating reports directly on your machine.

What is the best way to interpret pharmacogenomics drug-gene interactions locally?

The best way to interpret pharmacogenomics drug-gene interactions locally is using offline DNA analysis tools that process raw consumer data. This generates actionable medication guidance and agent-friendly JSON exports without cloud data transfers.