Perform genomic interval arithmetic and bioinformatics file I/O on Polars DataFrames.
npx skills add https://github.com/Hung-3008/agusta --skill polars-bio-hung-3008
Please help me install this Agent Skill. Skill: polars-bio Source: https://github.com/Hung-3008/agusta/tree/main/.agents/skills/polars-bio Command: npx skills add https://github.com/Hung-3008/agusta --skill polars-bio-hung-3008
High-performance genomic interval operations and bioinformatics I/O on Polars DataFrames, enabling fast overlap, nearest, merge, coverage, complement, and subtract workflows for BED, VCF, BAM, GFF among others with streaming and cloud-native capabilities.
Install polars-bio and run a quick overlap example on two interval sets to validate results.
High-intent search queries and answers about installing and using this skill.
Genomic interval operations on Polars DataFrames are performed using modular functional and method-chaining APIs to execute overlap, nearest, merge, coverage, complement, and subtract workflows with high-speed DataFusion acceleration.
Yes, you can stream VCF, BAM, and BED files directly from cloud-native S3, GCS, or Azure storage with compression support, enabling high-speed bioinformatics I/O without downloading entire datasets locally first.
Streaming I/O with optional Lazy execution allows you to process large-scale genomic datasets that exceed memory limits by performing interval operations and file I/O incrementally rather than loading everything into memory.
SQL integration via DataFusion allows you to query registered bioinformatics files as tables and combine SQL logic directly with genomic interval operations on Polars DataFrames for complex analytical workflows.
Coordinate-system metadata management ensures accurate genomic interval arithmetic results by tracking and aligning coordinate frameworks across overlapping, nearest, and coverage operations performed on DataFrames.
Pileup depth computation from BAM and CRAM files is supported natively, allowing you to calculate read depth directly within large-scale genomic data processing pipelines on Polars DataFrames.
swaruplabPerform genomic interval operations and stream BED/VCF/BAM/GFF files with Polars and DataFusion.
RamanEbrahimiPerform genomic interval operations and bioinformatics file I/O on Polars DataFrames.
Lord1EgyptPerform genomic interval arithmetic and stream BED, VCF, and BAM files with Polars.
galeepPerform genomic interval operations and bioinformatics file I/O with Polars DataFrames.
