One-click install
npx skills add https://github.com/Estrella-231/Mathematical_modeling_tongmeng --skill primekg-estrella-231
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: primekg
Source: https://github.com/Estrella-231/Mathematical_modeling_tongmeng/tree/main/.agents/skills/primekg
Command: npx skills add https://github.com/Estrella-231/Mathematical_modeling_tongmeng --skill primekg-estrella-231

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill requires pandas, os, json, and includes scripts (resource) components.

What problem does it solve?

PrimeKG helps you search and connect multiscale biomedical entities (genes, drugs, diseases, phenotypes) to generate evidence-backed hypotheses for mechanisms and repurposing.

Core Features & Use Cases

  • Entity Search (genes/drugs/diseases/phenotypes): Locate relevant nodes by name and optional type, then use the returned IDs for downstream graph queries.
  • Neighborhood Retrieval: Pull direct associations for a chosen entity to inspect relationship types and sources.
  • Disease Context Summaries: Compile associated genes, drugs, phenotypes, and related diseases for a disease name in one shot (useful for quick literature-style grounding).
  • Use Cases: Drug discovery target finding, drug repurposing candidate exploration, phenotype-to-disease interpretation, and network pharmacology-style mapping from molecular targets to clinical outcomes.

Quick Start

Use primekg to summarize Alzheimer’s disease context and return associated genes, drugs, and phenotypes from the knowledge graph by asking your assistant to run the disease context workflow for the query name "Alzheimer's disease".

Frequently Asked Questions about primekg

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I find drug repurposing candidates using a biomedical knowledge graph?

Drug repurposing candidates are found by querying a biomedical knowledge graph for direct drug-disease associations. You can retrieve a disease's context summary to compile associated drugs, genes, and phenotypes, generating evidence-backed hypotheses for new uses.

How does network pharmacology mapping work for connecting molecular targets to clinical outcomes?

Network pharmacology mapping works by retrieving direct associations between molecular targets and diseases within a biomedical knowledge graph. You locate a gene or drug node, pull its neighborhood to inspect relationship types, and trace paths to clinical disease outcomes.

Can I use pandas to query disease-gene associations locally without an API?

Yes, you can query disease-gene associations locally using pandas. The system relies on local CSV-based knowledge graph access, allowing you to search nodes, retrieve neighbors, and summarize disease contexts directly without external API dependencies.

What is the best way to interpret phenotype-to-disease relationships for precision medicine?

The best way to interpret phenotype-to-disease relationships is by querying a knowledge graph for direct associations. You can generate a disease context summary to compile associated phenotypes and related diseases, supporting precision medicine and mechanism interpretation.

How do I retrieve direct drug and gene associations for a specific disease name?

To retrieve direct drug and gene associations, run a disease context summary workflow using the specific disease name. This queries the knowledge graph to compile associated genes, drugs, phenotypes, and related diseases in one shot using the disease name.