rct-appraisal

Appraise randomized controlled trials across six integrated frameworks with dual validation.

7|3|Updated Jan 15, 2026

Search Tags:#grade #appraisal #consort #rct #tidier #rob2

Ready to run

npx skills add https://github.com/Zpankz/mcp-skillset --skill rct-appraisal

💬 Prompt for ChatGPT / Claude Chat▼

Please help me install this Agent Skill.
Skill: rct-appraisal
Source: https://github.com/Zpankz/mcp-skillset/tree/main/rct-appraisal
Command: npx skills add https://github.com/Zpankz/mcp-skillset --skill rct-appraisal

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill includes scripts (resource) and references (resource) components.

What problem does it solve?

Systematically appraises randomized controlled trials (RCTs) using integrated evaluation frameworks to identify bias, certainty, and safety signals, enabling rigorous decision-making for editors, guideline developers, and researchers.

Core Features & Use Cases

Six-framework integration: CONSORT 2025, RoB 2.0, GRADE, TIDieR, Benefits/Harms, COI in a single workflow.
Dual-validation with concordance analysis: Independent appraisers and structured resolution documentation.
Generates comprehensive reports, including GRADE summaries, NNT/NNH metrics, and editor-ready content for policy or manuscript preparation.

Quick Start

Load the randomized trial materials and run the six-framework appraisal pipeline to generate a comprehensive, editorial-ready appraisal report.

Frequently Asked Questions about rct-appraisal

High-intent search queries and answers about installing and using this skill.

FAQPage Schema

How do I appraise an RCT across multiple bias and reporting frameworks simultaneously?▼

The dual-validation mechanism uses independent appraisers to generate structured evidence logs, followed by concordance analysis to document resolution. This structured approach ensures rigorous bias assessment for peer-review, guideline development, and editorial writing.

How do I calculate NNT and NNH metrics for a systematic review or guideline development?▼

You can calculate NNT and NNH metrics by loading randomized trial materials and running the six-framework appraisal pipeline. The workflow generates comprehensive editorial-ready reports containing GRADE summaries, NNT/NNH metrics, and editor-ready content for policy or manuscript preparation.

Can I use this workflow for systematic reviews and peer-review manuscript preparation?▼

Yes, this workflow is designed for peer-review, guideline development, systematic reviews, and editorial writing. It appraises randomized controlled trials using six integrated frameworks to provide structured bias assessment and downloadable comprehensive reports.

What is the best way to assess risk of bias using RoB 2.0 and CONSORT 2025 for evidence grading?▼

The best way to assess risk of bias using RoB 2.0 and CONSORT 2025 is through an integrated appraisal pipeline. This workflow evaluates RCT quality and certainty using six frameworks, including RoB 2.0 for bias assessment and CONSORT 2025 for reporting quality, generating a comprehensive appraisal report.

Do I need dual-validation to perform structured bias assessment for RCTs?▼

Dual-validation is not strictly required but is recommended for rigorous bias assessment. It involves independent appraisers generating structured evidence logs and concordance analysis to document resolution, ensuring reliable RCT appraisal for peer-review and guideline development.

What are the limitations of using integrated appraisal frameworks for RCT evaluation?▼

Integrated appraisal frameworks for RCT evaluation are limited to six specific frameworks: CONSORT 2025, RoB 2.0, GRADE, TIDieR, Benefits/Harms, and COI. They require complete randomized trial materials to generate accurate bias assessments and comprehensive reports.