reactome-database

Query and analyze biological pathways from the Reactome database via REST APIs.

Updated Dec 17, 2025
One-click install
npx skills add https://github.com/robotlearning123/claude-scientific-skills --skill reactome-database-robotlearning123
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: reactome-database
Source: https://github.com/robotlearning123/claude-scientific-skills/tree/main/scientific-skills/reactome-database
Command: npx skills add https://github.com/robotlearning123/claude-scientific-skills --skill reactome-database-robotlearning123

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill requires reactome2py, and includes scripts (resource) and references (resource) components.

What problem does it solve?

This Skill solves the problem of querying and analyzing complex biological pathways and data from the Reactome database, making it easier for users to perform systems biology research.

Core Features & Use Cases

  • Pathway Querying: Retrieve detailed information about biological pathways, reactions, and entities.
  • Pathway Analysis: Perform overrepresentation and expression analysis on gene lists and expression data.
  • Species Comparison: Compare pathway data across different organisms.
  • API Access: Utilize Reactome's Content and Analysis Services via REST API or Python client library.
  • Use Case: A researcher wants to identify enriched pathways from a list of genes associated with a disease and compare them across different species.

Quick Start

Use the reactome-database skill to analyze the overrepresentation of pathways from a list of genes associated with a disease.

Frequently Asked Questions about reactome-database

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I perform pathway enrichment analysis on a list of disease-associated genes?

To perform pathway enrichment analysis, submit your gene list to the Reactome Content and Analysis Services. This Skill queries the Reactome database to identify overrepresented biological pathways and reactions associated with your input genes.

What is Reactome pathway analysis and how does it support systems biology research?

Reactome pathway analysis retrieves and evaluates biological pathways, reactions, and entities to support systems biology research. It enables pathway querying, expression analysis, and species comparison to identify enriched biological mechanisms across organisms.

Can I compare biological pathways across different species using the Reactome database?

Yes, you can compare biological pathway data across different species using the Reactome database. This Skill supports species comparison, allowing researchers to contrast pathway reactions and entities to identify conserved or divergent biological mechanisms.

Do I need Python and the reactome2py library to access Reactome REST APIs?

You need Python and the reactome2py library to programmatically access Reactome REST APIs. Alternatively, you can directly use Reactome's Content and Analysis Services REST APIs without the Python client, depending on your preferred environment setup.

What's the best way to retrieve detailed information about biological reactions from Reactome?

The best way to retrieve detailed biological reaction information is by querying the Reactome database via its Content Service. This Skill facilitates pathway retrieval, allowing you to extract specific details about reactions, entities, and broader biological pathways.