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retrosynthesis-guide

Plan retrosynthetic routes for target molecules using Corey's disconnections and AI tools.

Updated Mar 20, 2026
Search Tags:#education#retrosynthesis#ai-tools#disconnections#organic-synthesis#reaction-prediction#coreys-logic
One-click install
npx skills add https://github.com/liongkj/zotero-library-bridge-skills --skill retrosynthesis-guide
Or copy as Structured Prompt for Agentā–¼
Please help me install this Agent Skill.
Skill: retrosynthesis-guide
Source: https://github.com/liongkj/zotero-library-bridge-skills/tree/main/skills/retrosynthesis-guide
Command: npx skills add https://github.com/liongkj/zotero-library-bridge-skills --skill retrosynthesis-guide

SYSTEM DOCUMENTATION & REQUIREMENTS

What problem does it solve?

It helps researchers plan synthetic routes and predict feasible retrosynthetic steps using Corey's logic and AI-driven tools.

Core Features & Use Cases

  • Classic disconnection strategies (FGI, C-C bond, ring disconnections) applied to target molecules.
  • Integrates leading retrosynthesis tools (ASKCOS, IBM RXN, AiZynthFinder) to propose routes and evaluate feasibility.
  • Educational guidance and step-by-step planning for method development and teaching retrosynthesis concepts.
  • Use Case: A chemist wants to plan a synthesis for a complex target and compare alternative routes with available building blocks.

Quick Start

Provide a target molecule as SMILES or structure and I will generate a retrosynthetic route with proposed precursors.

Frequently Asked Questions about retrosynthesis-guide

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I plan a retrosynthetic route for a target molecule?ā–¼

Retrosynthesis planning combines Corey's classic disconnection strategies, such as FGI and C-C bond cleavage, with AI-assisted predictions to break down a target molecule into commercially available or simpler precursors step-by-step.

Can I use AI retrosynthesis tools to evaluate the feasibility of proposed synthetic routes?ā–¼

Yes, this approach integrates AI retrosynthesis tools like ASKCOS, IBM RXN, and AiZynthFinder to propose alternative routes and evaluate the feasibility of reaction steps for your target molecule.

How do I apply Corey's disconnection logic to complex organic synthesis targets?ā–¼

You apply Corey's disconnection logic by identifying strategic bond disconnections, including functional group interconversions and ring disconnections, to systematically simplify complex organic synthesis targets into manageable precursors.

What format should I use to input a target molecule for AI-assisted retrosynthesis?ā–¼

You should input your target molecule using the SMILES string format or a chemical structure representation, which allows the retrosynthesis engine to process the molecular data and generate the corresponding synthetic routes.

Is this retrosynthesis planning approach suitable for teaching organic synthesis concepts?ā–¼

Yes, this approach provides educational guidance and step-by-step planning for teaching retrosynthesis concepts, making it suitable for both academic instruction and practical method development in organic chemistry research.

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