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scientific-regulatory-genomics

Integrate RegulomeDB, ReMap, and 4DN data to score noncoding variants.

3|1|Updated Feb 11, 2026
Search Tags:#variant-analysis#tf-binding#remap#regulatory-genomics#regulomedb#fourdn
One-click install
npx skills add https://github.com/nahisaho/satori --skill scientific-regulatory-genomics
Or copy as Structured Prompt for Agent▼
Please help me install this Agent Skill.
Skill: scientific-regulatory-genomics
Source: https://github.com/nahisaho/satori/tree/main/src/.github/skills/scientific-regulatory-genomics
Command: npx skills add https://github.com/nahisaho/satori --skill scientific-regulatory-genomics

SYSTEM DOCUMENTATION & REQUIREMENTS

What problem does it solve?

Regulatory genomics information is scattered across RegulomeDB, ReMap, and 4D Nucleome data sources; this pipeline unifies scoring, TF binding mapping, and 3D genome analysis for noncoding variant interpretation.

Core Features & Use Cases

  • RegulomeDB variant scoring to prioritize regulatory potential.
  • ReMap TF binding mapping to identify transcription factor occupancy in regions of interest.
  • 4D Nucleome based 3D genome structure analysis to contextualize regulatory variants.
  • End-to-end regulatory-variant integration pipeline that outputs consolidated results for downstream interpretation.

Quick Start

Invoke regulatory_variant_pipeline with a list of variants to compute RegulomeDB scores, map TF bindings, and retrieve 4D Nucleome interactions.

Frequently Asked Questions about scientific-regulatory-genomics

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I score noncoding variants for regulatory potential using RegulomeDB?▼

You can score noncoding variants for regulatory potential by invoking the regulatory_variant_pipeline with a list of variants to automatically compute RegulomeDB scores.

What is the best way to map transcription factor binding sites near genetic variants?▼

ReMap TF binding mapping identifies transcription factor occupancy in regions of interest by retrieving ReMap peaks alongside variant scores in a consolidated regulatory pipeline.

Can I analyze 3D genome structure and 4D Nucleome data for variant interpretation?▼

Yes, 4D Nucleome experiment search retrieves 3D genome structure data to contextualize regulatory variants within higher-order chromatin interactions during noncoding variant interpretation.

How do I integrate regulatory genomics data from RegulomeDB, ReMap, and 4DN in one workflow?▼

The regulatory_variant_pipeline integrates RegulomeDB, ReMap, and 4DN data sources into an end-to-end workflow that outputs consolidated regulatory-variant results for downstream interpretation.

Does this regulatory genomics pipeline require specific input formats for variant lists?▼

This regulatory genomics pipeline requires a list of variants as input to compute RegulomeDB scores, map TF bindings, and retrieve 4D Nucleome interactions without external dependencies.

When do I need regulatory genomics analysis for noncoding variant interpretation?▼

Regulatory genomics analysis is needed when interpreting noncoding variants to elucidate regulatory mechanisms by scoring variant potential, mapping TF bindings, and analyzing 3D genome structure.

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