scikit-bio

Analyze biological sequences and microbiome data from raw reads to comparative statistics.

74|5|Updated Dec 10, 2025
One-click install
npx skills add https://github.com/dralkh/seerai --skill scikit-bio-dralkh
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: scikit-bio
Source: https://github.com/dralkh/seerai/tree/main/skills/scikit-bio
Command: npx skills add https://github.com/dralkh/seerai --skill scikit-bio-dralkh

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill includes references (resource) components.

What problem does it solve?

Scikit-bio removes the friction of moving between sequence data, phylogenetic trees, diversity metrics, ordination, and statistical tests so researchers can analyze biological datasets in one workflow.

Core Features & Use Cases

  • Sequence and alignment analysis: Work with DNA, RNA, and protein sequences, including motif search, translation, and pairwise alignment.
  • Phylogenetics and community ecology: Build trees, calculate alpha and beta diversity, compute UniFrac, run PCoA, and perform PERMANOVA or Mantel tests.
  • File interoperability: Read and write FASTA, FASTQ, Newick, BIOM, and other common bioinformatics formats.
  • Use case: A microbiome researcher can move from a BIOM table and tree to diversity summaries, ordination plots, and significance testing without switching libraries.

Quick Start

Use the scikit-bio skill to analyze a microbiome dataset by reading the table and tree, calculating diversity, and summarizing the results in plain language.

Frequently Asked Questions about scikit-bio

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I calculate alpha and beta diversity from a microbiome dataset?

You can calculate alpha and beta diversity by reading a BIOM table and phylogenetic tree, then computing diversity metrics and ordination plots in one workflow. This process integrates tree-aware distance calculations like UniFrac.

How do I perform statistical tests like PERMANOVA and Mantel on biological distance matrices?

To perform PERMANOVA and Mantel tests on biological distance matrices, you apply distance-based hypothesis testing directly to your ordination results. This validates whether sample groupings in your microbiome data are statistically significant.

What's the best way to parse and validate common bioinformatics file formats like FASTA, FASTQ, and Newick?

The best way to parse and validate bioinformatics file formats like FASTA, FASTQ, and Newick is using validated biological file I/O operations. This ensures reproducible analysis by reading and writing sequence, alignment, and tree data accurately.

Can I analyze DNA, RNA, and protein sequences including motif search and translation in one workflow?

Yes, you can analyze DNA, RNA, and protein sequences including motif search, translation, and pairwise alignment in one workflow. This sequence and alignment analysis integrates directly with downstream phylogenetics and community ecology tasks.

How do I run ordination analysis such as PCoA on microbiome distance data?

To run ordination analysis such as PCoA on microbiome distance data, you compute distance metrics from your biological table and project them into lower dimensions. This yields ordination plots for visualizing sample relationships.

Does this approach support building phylogenetic trees and computing UniFrac distances for community ecology?

Yes, this approach supports building phylogenetic trees and computing UniFrac distances for community ecology. You can move from raw sequence data to tree building and then calculate taxonomy-aware distance metrics seamlessly.