What problem does it solve?
TileDB-VCF solves the problem of storing, querying, and exporting large genomic variant datasets efficiently without repeatedly merging bulky VCF files or sacrificing query performance. It is designed for researchers who need fast access to cohort-scale variant data across regions, samples, and annotations.
Core Features & Use Cases
- Scalable ingestion: Build datasets from single-sample VCF or BCF files and add new samples incrementally.
- Fast querying: Retrieve variants by genomic region, sample set, or selected attributes with parallel performance.
- Export and interoperability: Export subsets back to VCF or other analysis-friendly outputs for downstream tools.
- Use cases: Population genomics, cohort analysis, rare variant filtering, quality control, and review of cloud-hosted variant datasets.
Quick Start
Use the tiledbvcf skill to create a dataset from indexed single-sample VCF files, query a genomic region, and export the matching variants for analysis.