transcription-factor-enrichment
CommunityIdentify TF drivers for your gene list.
Data & Analytics#bioinformatics#network-visualization#gene-list#transcription-factor#enrichment-analysis#chea3#dorothea
AuthorMDhewei
Version1.0.0
Installs0
System Documentation
What problem does it solve?
Identifies transcription factors likely regulating a provided gene list through enrichment analysis against ChEA3 API and built-in DoRothEA regulons.
Core Features & Use Cases
- Dual-method enrichment: online ChEA3 API-based analysis plus a built-in DoRothEA TF-target regulon for offline reproducibility.
- Comprehensive outputs: a ranked TF table with p-values, FDR, overlap details, and ready-to-use visualizations (TF–gene network and bar chart).
- Use Case: interpret DEGs from RNA-seq to prioritize TFs for follow-up experiments (CRISPR perturbations, ChIP-seq targets) and generate publication-quality figures.
Quick Start
Provide your gene list and run the analysis to obtain enriched TFs, statistics, and visualizations.
Dependency Matrix
Required Modules
requestspandasnumpymatplotlib
Components
scripts
đź’» Claude Code Installation
Recommended: Let Claude install automatically. Simply copy and paste the text below to Claude Code.
Please help me install this Skill: Name: transcription-factor-enrichment Download link: https://github.com/MDhewei/bioinfor-claw/archive/main.zip#transcription-factor-enrichment Please download this .zip file, extract it, and install it in the .claude/skills/ directory.
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