airrflow

Runs nf-core/airrflow immune-repertoire analysis from raw reads or assembled data.

1|Updated Jun 19, 2026
One-click install
npx skills add https://github.com/danilomonge/nf-claw --skill airrflow
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: airrflow
Source: https://github.com/danilomonge/nf-claw/tree/main/pipelines/airrflow
Command: npx skills add https://github.com/danilomonge/nf-claw --skill airrflow

SYSTEM DOCUMENTATION & REQUIREMENTS

What problem does it solve?

This Skill removes the guesswork from running nf-core/airrflow, helping you analyze immune receptor sequencing data without hunting through docs or inventing flags.

Core Features & Use Cases

  • End-to-end AIRR analysis: Supports bulk and single-cell BCR and TCR workflows from raw reads or assembled inputs.
  • Reproducible pipeline execution: Uses the pinned release, schema-validated parameters, and provenance capture to keep runs consistent.
  • Broad analysis coverage: Handles V(D)J assignment, clonal inference, lineage reconstruction, genotype inference, novel allele detection, RNA-seq extraction, and reporting.
  • Practical scenario: Use it to process a TSV samplesheet, run the correct Nextflow command, and produce standardized results and MultiQC reports for a repertoire study.

Quick Start

Ask this skill to run nf-core/airrflow on your TSV samplesheet with the desired profile and output directory, and it will produce the correct invocation, validate the parameters, and preserve reproducibility.

Frequently Asked Questions about airrflow

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I run an nf-core immune repertoire analysis pipeline from raw reads?

To run an immune repertoire analysis, provide a valid TSV samplesheet and desired parameters. The skill generates the correct nf-core/airrflow Nextflow command, validates inputs against the schema, and executes the pipeline for reproducible results.

Can I use airrflow for both bulk and single-cell BCR TCR workflows?

Yes, airrflow supports both bulk and single-cell BCR and TCR workflows. It processes raw reads or assembled AIRR data to perform V(D)J assignment, clonal inference, and lineage reconstruction across various immune receptor sequencing data types.

What do I need to provide to start a Nextflow airrflow pipeline run?

You need a valid TSV samplesheet, a pinned pipeline version, and schema-validated parameters to start a Nextflow airrflow run. The skill uses these inputs to ensure reproducible execution and standardized output reporting.

How does the airrflow pipeline handle genotype inference and novel allele detection?

The airrflow pipeline handles genotype inference and novel allele detection as part of its broad analysis coverage. It applies these processes to immune repertoire data alongside clonal inference and lineage reconstruction during the Nextflow execution.

What is the best way to extract AIRR data from RNA-seq reads?

The best way to extract AIRR data from RNA-seq reads is using the nf-core/airrflow pipeline. The skill configures the RNA-seq-derived receptor extraction process, ensuring the correct Nextflow command runs with schema-validated parameters for accurate results.

Why should I use schema-validated parameters for immune repertoire Nextflow pipelines?

Schema-validated parameters ensure reproducible pipeline execution by preventing invalid configurations. Using a pinned release and provenance capture, the skill keeps your nf-core/airrflow runs consistent and avoids errors from incorrect flags or unsupported settings.