alphafold2

Predict protein structures from FASTA sequences using the AlphaFold2 model.

Updated Aug 27, 2026
One-click install
npx skills add https://github.com/guanxiaol/open-science --skill alphafold2
Or copy as Structured Prompt for Agent
Please help me install this Agent Skill.
Skill: alphafold2
Source: https://github.com/guanxiaol/open-science/tree/main/runtime/skills/alphafold2
Command: npx skills add https://github.com/guanxiaol/open-science --skill alphafold2

SYSTEM DOCUMENTATION & REQUIREMENTS

💡 This Skill requires gpu, and includes scripts (resource) and references (resource) components.

What problem does it solve?

This Skill addresses the challenge of predicting protein structures, which is crucial for various biological and medical applications.

Core Features & Use Cases

  • Protein Structure Prediction: Accurately predict the three-dimensional structure of proteins using the AlphaFold2 model.
  • Sequence Validation: Validate designed sequences using self-consistency pLDDT, ipTM, and RMSD metrics.
  • Quick Prediction: Run a quick multiple sequence alignment (MSA)-backed prediction using the public MMseqs2 server.
  • Use Case: For researchers in the field of molecular biology, this Skill can be used to predict the structure of a protein sequence and validate the design of a protein for further experiments.

Quick Start

Run the AlphaFold2 prediction for the sequence in 'input.fasta' and output the results to 'out'.

Frequently Asked Questions about alphafold2

High-intent search queries and answers about installing and using this skill.

FAQPage Schema
How do I predict protein structures from a sequence using AlphaFold2?

To predict protein structures, run AlphaFold2 on an input.fasta file to generate 3D models. The Skill utilizes the AlphaFold2 model to output structural predictions to a specified directory.

Do I need a GPU to run AlphaFold2 for protein structure prediction?

Yes, a GPU is required for efficient protein structure prediction using AlphaFold2. The computational demands of the AlphaFold2 model necessitate GPU acceleration to process sequences effectively.

Can I validate designed protein sequences using AlphaFold2 metrics?

Yes, AlphaFold2 validates designed protein sequences using self-consistency metrics like pLDDT, ipTM, and RMSD. These metrics assess the structural confidence and accuracy of your predicted models.

How does multiple sequence alignment work for quick protein structure prediction?

AlphaFold2 performs quick protein structure prediction by running multiple sequence alignment (MSA) using the public MMseqs2 server. This MSA-backed approach accelerates the prediction process for your sequences.

What are the limitations of using the public MMseqs2 server for AlphaFold2 MSA?

AlphaFold2 relies on the public ColabFold MSA server for multiple sequence alignment, meaning predictions depend on server availability. This external dependency may impact processing speed during high-traffic periods.

Is AlphaFold2 suitable for molecular biology research and drug discovery?

Yes, AlphaFold2 is suitable for molecular biology research and drug discovery. It accurately predicts protein structures, providing essential structural insights for designing experiments and therapeutics.