Project genome data onto 1000 Genomes reference panels for ancestry analysis.
npx skills add https://github.com/exon-research/genomi --skill ancestry
Please help me install this Agent Skill. Skill: ancestry Source: https://github.com/exon-research/genomi/tree/main/skills/ancestry Command: npx skills add https://github.com/exon-research/genomi --skill ancestry
This Skill provides tools for analyzing and projecting ancestry from genome data, offering insights into population context and reference panel similarity.
Analyze the ancestry of your genome using the ancestry skill and provide the genome source file.
High-intent search queries and answers about installing and using this skill.
You can estimate ancestry from genome data by applying PCA projection and marker overlap quality control against 1000 Genomes reference panels. This provides a qualitative assessment of your population context and origin.
PCA projection in genomics maps your genome data onto 1000 Genomes reference panels to estimate population context. It identifies reference-neighbor similarity to provide qualitative ancestry insights and population origin estimates.
Yes, ancestry analysis requires access to specific 1000 Genomes reference panels, including ancestry-1000g-30x-grch38 and ancestry-1000g-30x-grch37. These panels provide the baseline population data needed for PCA projection.
Yes, you can use GRCh37 genome data for ancestry analysis with the ancestry-1000g-30x-grch37 reference panel. The Skill also supports GRCh38 data and includes liftover-chains for coordinate conversion between genome builds.
Marker overlap quality control ensures your genome data aligns correctly with the 1000 Genomes reference panels before PCA projection. Without this step, mismatched genetic markers could skew your ancestry and population context results.
The best way to estimate population origin is using local ancestry reference-panel tools that perform PCA projection and marker overlap QC. This approach compares your genome against 1000 Genomes data to determine reference-neighbor similarity.
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ClawBioCompute identity-by-state similarity between 23andMe genotype files and reference genomes.
MubasherMohammedAnalyze population genetic structure with PCA against SGDP data.
